azo0655 protein (Azoarcus sp. BH72) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

azo0655

Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...] (1167 aa)

Predicted Functional Partners:

azo1817

0.997

barA

0.997

azo2457

0.997

azo2482

0.997

gacS

0.997

azo3685

0.997

azo2450

0.996

azo3381

0.996

azo1490

0.995

azo1662

0.995

Your Current Organism:

Azoarcus sp. BH72

NCBI taxonomy Id: 62928
Other names: A. sp. BH72

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
azo0655	azo1490	azo0655	azo1490	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	0.995
azo0655	azo1662	azo0655	azo1662	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative two-component system sensor protein, 3 Signal P reporting signal peptide. TMHMM reporting 1 transmembrane helices; Function unclear.	0.995
azo0655	azo1817	azo0655	azo1817	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Conserved hypothetical two-component hybrid sensor and regulator. Homology to ebA6890 of Azoarcus sp. EbN1 of 56% (gnl\|keqq\|eba:ebA6890(KEGG)). InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR009082 His_kin_homodim. IPR001610 PAC. IPR000700 PAS-assoc_C. IPR000014 PAS_domain. IPR001789 Response_reg. Pfam: PF02518 HATPase_c. PF00512 HisKA. PF00785 PAC. PF00989 PAS. PF00072 Response_reg. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00086 PAC. SM00091 PAS. SM00448 REC. TIGRFAM: TIGR00229 sensory_box; 3 TMHMM reporting 7 transmembra [...]	0.997
azo0655	azo2450	azo0655	azo2450	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative two-component system sensor protein,; Function unclear.	0.996
azo0655	azo2457	azo0655	azo2457	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative sensory box histidine kinase,; Function unclear.	0.997
azo0655	azo2482	azo0655	azo2482	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...]	0.997
azo0655	azo3381	azo0655	azo3381	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Hypothetical signaling protein.	0.996
azo0655	azo3685	azo0655	azo3685	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative hybrid sensor and regulator protein, MmoS) InterPro: IPR003594; ATPbind_ATPase. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR008207; Hpt. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. IPR001789; Response_reg. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00785; PAC. PF00989; PAS. PF00072; Response_reg. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00073; HPT. SM00086; PAC. SM00091; PAS. SM00448; REC. TIGRFAM: TIGR00229; sensory_box. TMHMM reporting 2 transmembrane helices; Family membership.	0.997
azo0655	barA	azo0655	azo2402	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative sensor-regulator protein,; Specificity unclear.	0.997
azo0655	gacS	azo0655	azo2575	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	Putative two-component hybrid sensor and regulator,; Family membership.	0.997
azo1490	azo0655	azo1490	azo0655	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative two-component sensor histidine kinase protein. TrEMBL; Q87XU6(47% identity, 64% similarity),Q6F9J5(43% identity,61% similarity),Q6NAD6(44% Identity,61% similarity). TMHMM2 reporting 2 TMH's present. No Signal peptide Present. Has PF02133;Permease for cytosine/purines, uracil, thiamine, allantoin: IPR001248;Cyt_pur_permease:The Nucleobase Cation Symporter-1 (NCS1) family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have [...]	0.995
azo1490	azo1662	azo1490	azo1662	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative two-component system sensor protein, 3 Signal P reporting signal peptide. TMHMM reporting 1 transmembrane helices; Function unclear.	0.997
azo1490	azo1817	azo1490	azo1817	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Conserved hypothetical two-component hybrid sensor and regulator. Homology to ebA6890 of Azoarcus sp. EbN1 of 56% (gnl\|keqq\|eba:ebA6890(KEGG)). InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR009082 His_kin_homodim. IPR001610 PAC. IPR000700 PAS-assoc_C. IPR000014 PAS_domain. IPR001789 Response_reg. Pfam: PF02518 HATPase_c. PF00512 HisKA. PF00785 PAC. PF00989 PAS. PF00072 Response_reg. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00086 PAC. SM00091 PAS. SM00448 REC. TIGRFAM: TIGR00229 sensory_box; 3 TMHMM reporting 7 transmembra [...]	0.997
azo1490	azo2450	azo1490	azo2450	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative two-component system sensor protein,; Function unclear.	0.997
azo1490	azo2457	azo1490	azo2457	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative sensory box histidine kinase,; Function unclear.	0.998
azo1490	azo2482	azo1490	azo2482	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...]	0.998
azo1490	azo3381	azo1490	azo3381	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Hypothetical signaling protein.	0.998
azo1490	azo3685	azo1490	azo3685	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative hybrid sensor and regulator protein, MmoS) InterPro: IPR003594; ATPbind_ATPase. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR008207; Hpt. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. IPR001789; Response_reg. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00785; PAC. PF00989; PAS. PF00072; Response_reg. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00073; HPT. SM00086; PAC. SM00091; PAS. SM00448; REC. TIGRFAM: TIGR00229; sensory_box. TMHMM reporting 2 transmembrane helices; Family membership.	0.998
azo1490	barA	azo1490	azo2402	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative sensor-regulator protein,; Specificity unclear.	0.998
azo1490	gacS	azo1490	azo2575	Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl\|keqq\|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.	Putative two-component hybrid sensor and regulator,; Family membership.	0.998

page 1 of 6

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About