STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
azo0668Conserved hypothetical phoshpatidate cytidyltransferase. Homology to pa2536 of P. aeruginosa (trembl|Q9I0U8). Phosphatidate cytidylyltransferase is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA): CTP + phosphatidate = diphosphate + CDP-diacylglycerol Pfam: Phospatidate cytidyltransferase signal peptide 7 TMHs InterPro: Phosphatidate cytidylyltransferase stp: serine transporter; Family membership. (314 aa)    
Predicted Functional Partners:
azo0667
Putative acyltransferase; FUNCTION: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl carrier protein as the fatty acyl donor. CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. Entry name:-SWISSPROT:PLSC_ECOLI Prim. accession # P26647 InterPro:-IPR002123; Acyltransferase. IPR004552; AGP_acyltrn. Pfam:-PF01553; Acyltransferase; 1. Identities = 42/127 (33%) Prediction: Non-secretory protein Signal peptide probability: 0. [...]
 
 
  0.995
azo0663
Probable CDP-alcohol phosphatidyltransferase family protein; Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. Entry name Q8PQ18 Primary accession number: Q8PQ18 InterPro IPR000462; CDP-OH_P_trans. Pfam PF01066; CDP-OH_P_transf; 1. Identities = 114/203 (56%),Prediction: Signal peptide Signal peptide probability: 0.988 Number of predicted TMHs: 3; Family membership.
 
 
 0.987
azo0665
Conserved hypothetical protein; Entry name:- Q9I0U5 Primary accession number:-Q9I0U5 InterPro:- IPR008934; AcPase_VanPerase. IPR000340; DS_phosphatase. IPR000326; PA_PTPase. Number of predicted TMHs: 8 Prediction: Non-secretory protein Signal peptide probability: 0.061 IPR000387; TYR_phosphatase. Pfam PF00782; DSPc; 1. PF01569; PAP2; 1. Identity:- 58%.
 
 
  0.969
azo0664
Conserved hypothetical protein; Similar to TREMBL:Q87TY0 (64% identity); TREMBL:Q8PQ17 (61% identity); SWISSPROT:P76092 (55% identity).
 
    0.947
pgsA
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGP synthase). It catalyses the conversion of CDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the commited step to the synthesis of acidic phospholipids. It is an integral membrane protein. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. Entry name :-SWISSPROT:PGSA_ECOLI Prim. accession # P06978 Identities = 50% InterPro IPR000462; CDP-OH_P_trans. I [...]
  
 
  0.903
azo0788
Probable acyltransferase; Acyl-[acyl-carrier protein] can also acts as acyl donor.The animal enzyme is specific for the transfer of unsaturated fatty acyl groups. Catalytic Activity:-Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. Entry name TREMBL:Q82VB2 Prim. accession # Q82VB2 InterPro:-IPR002123; Acyltransferase. Pfam:- PF01553; Acyltransferase; 1. Identity:- 56% Prediction: Signal peptide Signal peptide probability: 0.907 Number of predicted TMHs: 1; Family membership.
  
 
  0.753
plsC
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase; Function:-Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position (By similarity). CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. Entry name:- PLSC_NEIGO Primary accession number :- Q59601 InterPro IPR002123; Acyltransferase. IPR004552; AGP_acyltrn. Pfam PF01553; Acyltransferase; 1. Identities = 68/182 (37%) Prediction: Non-secretory protein Signal peptide probability: 0.096 Number of predicted TMHs: 0; Family membership.
  
 
  0.741
aas
AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...]
 
 
  0.719
azo0148
Putative acyltransferase family protein; Similar to the Aas bifunctional protein [includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-gpe acyltransferase); acyl-acyl carrier protein synthetase (acyl-acp synthetase)].Plays a role in lysophospholipid acylation. 25% Acyltransferase.IPR000873; AMP-bind. Pfam:PF01553; Acyltransferase; 1.PF00501; AMP-binding; 1. TMhelix:10; Function unclear.
 
 
 0.711
azo0666
Conserved hypothetical membrane protein. Homology to PA2538 of Pseudomonas aeruginosa of 36% (trembl|Q9I0U6). No domains predicted. No signal peptide. 3 TMHs; Conserved hypothetical protein.
       0.675
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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