STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ytfL1Probable hemolysin; Hypothetical protein ytfL. TREMBL:Q7NQ98: 61% identity, 78% similarity InterPro IPR002550; CBS. IPR000644; CBS_domain. IPR005170; CorC_transpt-asc. Pfam: PF00571; CBS; 2. PF03471; CorC_HlyC; PF01595; DUF21; gntP: gluconate transporter Signal peptide present (Signal P predicted) Transmembrane helices 4 (TMHMM predicted); High confidence in function and specificity. (431 aa)    
Predicted Functional Partners:
azo0029
Conserved hypothetical membrane protein; Similar to a tellurium resistance protein TerC. Belongs to the terC family. This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. Similar to a putative membrane protein TerC,80% identity to TrEMBL; Q5P410 from Azoarcus sp EnN1. 50% RNA_rec_mot.IPR005496; TerC. Pfam:PF03741; TerC; 1. TIGR:SPTO2691. TMHelix:5; Conserved hypothetical protein.
      0.871
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
 0.811
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.500
azo0681
Conserved hypothetical membrane protein. Homology to PP2796 of P. putida of 44% (trembl|Q88J53) PF04341,Protein of unknown function, DUF485;IPR007436;This family includes several putative integral membrane proteins. signal peptide 1 TMHs; Conserved hypothetical protein.
       0.473
azo0682
Conserved hypothetical sodium:solute symporter: Homology to an orf of P. aeruginosa of 72% (trembl|Q9APX1). Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gradient. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins,urea or anions, depending on the system. InterPro: Sodium:solute sympor [...]
       0.473
hpt
Hypoxanthine phosphoribosyltransferase (Hypoxanthine-guanine phosphoribosyltransferase. (HGPRTase) (IMP pyrophosphorylase) (IMP diphosphorylase) (Transphosphoribosidase) (Guanine phosphoribosyltransferase); Function unclear.
  
 
  0.451
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.446
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)] InterPro: AICARFT/IMPCHase bienzyme; High confidence in function and specificity.
    
  0.442
azo3964
Conserved Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.430
surE
Phosphoric-monoester phosphohydrolase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.427
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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