STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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Cooccurrence
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[Homology]
Score
icmFProbable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1088 aa)    
Predicted Functional Partners:
mutB
Probable Methylmalonyl-CoA mutase large subunit; FUNCTION: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (By similarity). ACtivity:- (R)-2-Methylmalonyl-CoA = succinyl-CoA Entry name :- MUTB_PORGI Primary accession number :-Q59677 Identities = 467/679 (68%) InterPro :-IPR006159; Acid_CoA_mut_C. IPR006158; B12-binding. IPR006099; MMCoA_mutase. IPR006098; MMCoA_mutase_N. IPR006100; MMCoA_mutase_sub. Pfam PF02310; B12-binding; 1. PF01642; MM_CoA_mutase; 1. Prediction: Non-secretory protein Signal [...]
 
0.999
azo2406
Conserved hypothetical pyruvate ferredoxin/flavodoxin oxidoreductase. Homology to bb4375 of B. bronchiseptica (trembl|Q7WFA5). CATALYZES THE FERREDOXIN-DEPENDENT OXIDATIVE DECARBOXYLATION OF ARYLPYRUVATES (BY SIMILARITY). Pfam: Pyruvate ferredoxin/flavodoxin oxidoreductase. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 
 0.968
azo3433
Conserved hypothetical pyruvate ferredoxin/flavodoxin oxidoreductase. Homology to rsc3122 of R. solanacearum (trembl|Q8XUR3). CATALYZES THE FERREDOXIN-DEPENDENT OXIDATIVE DECARBOXYLATION OF ARYLPYRUVATES (BY SIMILARITY). InterPro: Pyruvate ferredoxin/flavodoxin oxidoreductase (IPR002869). Pfam: Pyruvate ferredoxin/flavodoxin oxidoreductase. no singal peptide. no TMHs; Conserved hypothetical protein.
  
 
 0.968
xylE
Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir|JE0112 (52%), to trembl|Q45459 (48%)and to sprot|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.
    
 0.967
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
     
 0.945
cat1
Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership.
  
 
 0.930
azo3544
Probable 4-hydroxybutyrate coenzyme A transferase. Homology to cat2 of C. kluyveri of 43% (sprot|CAT2_CLOKL) InterPro: Acetyl-CoA hydrolase/transferase (IPR003702) Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHS; Family membership.
  
 
 0.930
argK
Putative LAO/AO transport system kinase. Homology to argK of E. coli (sprot|ARGK_ECOLI). In Escherichia coli K-12, the arginine-ornithine transport system requires an arginine-ornithine-binding protein and the lysine-arginine-ornithine (LAO) transport system includes a LAO-binding protein. Both periplasmic proteins can be phosphorylated by a single kinase, ArgK resulting in reduced levels of transport activity of the periplasmic transport systems that include each of the binding proteins. The ArgK protein acts as an ATPase enzyme and as a kinase. no signal peptide no TMHs; Family membership.
 
  
0.929
hppD
Probable 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4HPPD) (HPD) (HPPDase). Homology to hppD of Pseudomonas sp. of 56% (pir|S21209) Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. Pfam: Glaxolase/Bleomycin resistance protein no signal peptide no TMHs; Family membership.
    
 0.877
sucC
Probable succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.875
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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