Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
czcD1Putative cobalt-zinc-cadmium resistance protein; CzcD: Members of this family (TC 2.A.4) are integral membrane proteins that are found to increase tolerance to divalent metal ions such as cadmium, zinc,and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells. (Slc30a subfamily). Similar to the cobalt-zinc-cadmium resistance protein CzcD (cation efflux system protein) from Alcaligenes eutrophus (Ralstonia eutropha). SWISSPROT:CZCD_ALCEU.P13512. InterPro:IPR002524; Cation_efflux.InterPro: Cation efflux family. Pfam:PF01545; Cation_efflux; 1. TIGRFAMs:TI [...] (404 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
    0.816
azo0740
Similar to Rhodanese domain protein, a sulphurtransferase involved in cyanide detoxification. InterPro: Rhodanese/cdc25 fold; Specificity unclear.
       0.575
flgG
Flagellar basal-body rod protein flgG (Distal rod protein). The rod has been shown to consist of four different, yet evolutionary related proteins: in the distal portion of the rod there are about 26 subunits of protein flgG and in the proximal portion there are about six subunits each of proteins flgB, flgC, and flgF. These four proteins contain a highly conserved asparagine-rich domain at their N terminus. InterPro: Flagella basal body rod protein no signal peptide no TMHs; High confidence in function and specificity.
    
 
 0.506
glnA
Glutamine synthetase I (GS) plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. Similar to pir|G83005 (70%) and to pir|AJECQ (66%). Pfam (PF00120): Glutamine synthetase, catalytic domain Pfam (PF03951): Glutamine synthetase, beta-Grasp domain; High confidence in function and specificity.
     
 0.498
folP
Dihydropteroate synthase (EC 2.5.1.15) (DHPS) (Dihydropteroate pyrophosphorylase). DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity); High confidence in function and specificity.
     
  0.495
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK). InterPro: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase Pfam:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; High confidence in function and specificity.
     
  0.495
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
     
 0.461
nadA
Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
       0.434
cls1
Putative cardiolipin synthetase; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
  
    0.416
azo0742
Conserved hypothetical protein. Homology to rs04427 of R. solanacearum of 55% (trembl|Q8Y267). Pfam: Endonuclease/Exonuclease/phosphatase family (PF03372). Interpro: Endonuclease/Exonuclease/phosphatase family (IPR005135). no signal peptide. no TMHs.
       0.414
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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