Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo0846Membrane fusion protein; Similar to TREMBL:Q7NR61 (35% identity); TREMBL:Q8XYV3 (33% identity); TREMBL:Q88MQ4 (32% identity). InterPro (IPR006143): Secretion protein HlyD. SignalP predicting signal peptide. TC (2.A.6.1): The Heavy Metal Efflux (HME) Family; Family membership; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (362 aa)    
Predicted Functional Partners:
azo0847
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q9A7D5 (35% identity); TREMBL:Q9HXW4 (55% identity). Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TMHMM predicting 12 transmembrane helices. TC (2.A.6.2): The ( [...]
 
 0.985
macB
ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.953
tolC
Putative outer membrane effluxe protein protein. Homology to tolC from E. coli of 33%. The OEP family (outer membreane effluxe protein) allow export of a variety of substrates in Gram negative bacteria. TolC is believed to be a membre af an ABC transporter system for protein secretion without cleavage of a signal sequence. Pfam: Outer membrane efflux protein Signal peptide no TMHs; Family membership.
 
 0.928
azo2569
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family protein. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q92U15 (38% identity); TREMBL:Q7NE92 (38% identity). InterPro (IPR000731): Sterol-sensing 5TM box. InterPro (IPR004764): Hydrophobe/amphiphile efflux-1 HAE1. InterPro (IPR001036): Acriflavin resistance protein. Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophob [...]
  
 0.878
azo0784
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family protein. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q9A3K6 (38% identity); TREMBL:Q89XF8 (40% identity). InterPro (IPR001036): Acriflavin resistance protein. Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. T [...]
  
 0.855
aggA
Putative outer membrane efflux protein. Homology to aggA from P. putida of 35%. The OEP family (outer membrane efflux protein) allow export of a variety of substrates in Gram negative bacteria. InterPro: Outer membrane efflux protein Pfam: Outer membrane efflux protein signal peptide no TMHs; Function unclear.
  
 0.850
azo0245
RND efflux transporter, permease protein; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q8E8H2 (65% identity); SWISSPROT:P31224 (63% identity). InterPro (IPR001036): Acriflavin resistance protein. InterPro (IPR004764): Hydrophobe/amphiphile efflux-1 HAE1. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. Pfam (PF0 [...]
  
 0.842
azo3134
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q9HW27 (38% identity); SWISSPROT:Q57124 (33% identity). InterPro (IPR001036): Acriflavin resistance protein. Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TMHMM [...]
  
 0.834
azo2335
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family member. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q881X7 (44% identity); SWISSPROT:P76399 (48% identity). InterPro (IPR001036): Acriflavin resistance protein Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. [...]
  
 0.825
czcA2
Cobalt-zinc-cadmium resistance protein CzcA (cation efflux system protein CzcA). In A.eutrophus has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance.Czca and Czcb together would act in zinc efflux nearly as effectively as the complete czc efflux system (czcABC).Belongs to the acrb/acrd/acrf family. 41% similarity to the A.eutrophus CzcA protein. SWISSPROT:CZCA_ALCEU:P13511 InterPro: Heavy metal efflux pump CzcA. InterPro:IPR001036; Acrflvin_res.IPR004763: CzcA. Pfam:PF00873; ACR_tran; 1. InterPro:TIGR00914:Heavy meta [...]
 
 0.818
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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