node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
azo0926 | azo0929 | azo0926 | azo0929 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | 0.730 |
azo0926 | bamB | azo0926 | azo0930 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Conserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.780 |
azo0926 | engA | azo0926 | azo0931 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Probable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.690 |
azo0926 | gcpE | azo0926 | azo0927 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Probable 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.932 |
azo0926 | hisS | azo0926 | azo0928 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Histidine--tRNA ligase; Histidyl-tRNA synthetase. hisS, 75% idemtity to TrEMBL;Q5P7B4. Has Pfam;PF00587, tRNA synthetase class II core domain (G, H, P, S and T).Other tRNA synthetase sub-families are too disIPR002314,tRNA-synt_2b. Has Pfam;PF03129,Anticodon binding domain. This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases it is probably the anticodon binding domain; High confidence in function and specificity. | 0.788 |
azo0926 | ndk | azo0926 | azo0923 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.678 |
azo0926 | pilF | azo0926 | azo0925 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Type 4 pilus biogenesis protein,; Function unclear. | 0.830 |
azo0926 | rlmN | azo0926 | azo0924 | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.841 |
azo0929 | azo0926 | azo0929 | azo0926 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | 0.730 |
azo0929 | bamB | azo0929 | azo0930 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Conserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.979 |
azo0929 | engA | azo0929 | azo0931 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Probable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.862 |
azo0929 | gcpE | azo0929 | azo0927 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Probable 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.787 |
azo0929 | hisS | azo0929 | azo0928 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Histidine--tRNA ligase; Histidyl-tRNA synthetase. hisS, 75% idemtity to TrEMBL;Q5P7B4. Has Pfam;PF00587, tRNA synthetase class II core domain (G, H, P, S and T).Other tRNA synthetase sub-families are too disIPR002314,tRNA-synt_2b. Has Pfam;PF03129,Anticodon binding domain. This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases it is probably the anticodon binding domain; High confidence in function and specificity. | 0.969 |
azo0929 | ndk | azo0929 | azo0923 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.636 |
azo0929 | pilF | azo0929 | azo0925 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Type 4 pilus biogenesis protein,; Function unclear. | 0.763 |
azo0929 | rlmN | azo0929 | azo0924 | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.725 |
azo3965 | miaB | azo3965 | azo0778 | Coproporphyrinogen oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Conserved Hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.604 |
azo3965 | rlmN | azo3965 | azo0924 | Coproporphyrinogen oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.670 |
bamB | azo0926 | azo0930 | azo0926 | Conserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Transcriptional regulator, 36% identity to TrEMBL;Q88PJ8. Weak homology with other proteins spanning entire length. Prosite,PS50943; HTH_CROC1; The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors cro and C1 of temperate bacteriophages 434 and lambda, respectively; Specificity unclear. | 0.780 |
bamB | azo0929 | azo0930 | azo0929 | Conserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Conserved hypothetical protein; Putative membrane protein, 32% identity to TrEMBL;Q7WHN2. Signal Peptide present; Specificity unclear. | 0.979 |