STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nasFNitrate transport system, periplasmic-binding protein; Part of the ABC transporter complex NasFED involved in nitrate import. 59% Similar to the putative periplasmic-binding protein NasF in Klebsiella oxytoca. TREMBL:Q48466 InterPro:IPR010067; SsuA_fam.IPR006311; Tat. TIGRFAMs:TIGR01728; SsuA_fam; 1.TIGR01409; TAT_signal_seq; 1. Signal peptide present; High confidence in function and specificity. (419 aa)    
Predicted Functional Partners:
nasD
Putative nitrate transport system, ATP-binding protein; Part of the ABC transporter complex nasFED involved in nitrate import. 64% Similar to the nitrate transport membrane protein, nasD in Klebsella oxytoca. Probably responsible for energy coupling to the transport system. SWISSPROT:NASD_KLEOX.P39459. InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter.IPR005890; NtrCD. Pfam:PF00005; ABC_tran; 1. TIGRFAMs:TIGR01184; ntrCD; 1; High confidence in function and specificity.
 
 0.998
nasE
Nitrate transport permease protein nasE. 41% Similar to the nitrate permease protein, nrtB in Synechococcus sp.Part of the ABC transporter complex nrtBCD involved in nitrate import.Probably responsible for the translocation of the substrate across the membrane. SWISSPROT:NRTB_SYNP7.P38044. InterPro:IPR000515; BPD_transp.IPR005889; NtrB. Pfam:PF00528; BPD_transp; 1. TIGRFAMs:TIGR01183; ntrB; 1. TMHelix: 4; High confidence in function and specificity.
 
 
 0.997
nasA
Probable Nitrate reductase. Homology to nasA of K. oxytoca of 41% (sprot|NASA_KLEOX). Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants fungi and bacteria. InterPro: Prokaryotic molybdopterin oxidoreductases (IPR006655) Pfam: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain no signal peptide no TMH Helixturnhelix motif; High confidence in function and specificity; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
 
  
 0.929
tauB
Putative sulfonate transport system, ATP-binding protein; Part of the ABC transporter complex tauABC involved in taurine import as a sulfur source.Probably responsible for energy coupling to the transport system.Similar to the aliphatic sulfonate transport membrane protein, tauB in E.coli. Probably also involved in nitrate and bicarbonate transport; High confidence in function and specificity.
 
 0.929
tauC
Putative sulfonate transport system, permease protein; Part of the ABC transporter complex tauABC involved in taurine import as sulfur source. Probably responsible for the translocation of the substrate across the membrane.Similar to the aliphatic sulfonate permease protein, tauC in E.coli. Probably also involved in nitrate and bicarbonate transport; High confidence in function and specificity.
 
 
 0.900
azo3513
Putative aliphatic sulfonates transport system,ATP-binding protein; Region start changed from 3855391 to 3855571 (-180 bases).
 
 0.872
nasC
Putative nitrate reducatse small subunit. Homology to nasC of K. oxytoca of 38% (trembl|Q48467). NasC probably mediates electron transfer from NADH to NasA, the nitrate reductase. InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327) Pfam: Pyridine nucleotide-disulfide oxidoreductase no signal peptide no TMHs; Family membership.
 
 
 0.845
ssuC
Part of the ABC transporter complex ssuABC involved in aliphatic sulfonates import. Probably responsible for the translocation of the substrate across the membrane.26% Similar to the aliphatic sulfonates permease protein, ssuC in E.coli. SWISSPROT:SSUC_ECOLI: P75851 InterPro:IPR000515; BPD_transp. Pfam:PF00528; BPD_transp; 1. InterPro:PF00528: Binding-protein-dependent transport systems inner membrane component. TMhelix:6; Specificity unclear.
 
 
 0.822
azo0941
Probable nitrate regulatory protein,; High confidence in function and specificity.
 
  
 0.775
nirB
Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4). 76% EGF_like.IPR001327; FAD_pyr_redox. IPR007419;Fer2_BFD.IPR006066; Nir_Si.IPR006067; Nir_Sir_4Fe4S. IPR005117; NiR_SiR_beta_fer. IPR001100; Pyr_redox. Pfam: PF04324; Fer2_BFD; 1.PF01077; NIR_SIR; 1.PF03460; NIR_SIR_ferr; 1. PF00070; Pyr_redox; 1. In E.coli, the NADH-dependent nitrite reductase catalyzes the six-electron reduction of nitrite to ammonia and also catalyzes the two-electron reduction of hydroxylamine to ammonia. The enzyme is a FAD-flavoprotein, and also contains a siroheme and one 2Fe-2S center; High confidence in [...]
 
 
 0.651
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.