Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sspA2Probable Stringent starvation protein A. Homology to sspA of E. coli of 43% (sprot|SSPA_ECOLI). FORMS AN EQUIMOLAR COMPLEX WITH THE RNA POLYMERASE HOLOENZYME (RNAP) BUT NOT WITH THE CORE ENZYME. IT IS SYNTHESIZED PREDOMINANTLY WHEN CELLS ARE EXPOSED TO AMINO ACID STARVATION AT WHICH TIME IT ACCOUNTS FOR OVER 50% OF THE TOTAL PROTEIN SYNTHESIZED. Pfam: Glutatione S-transferase,N-terminale domaine no TMHs; Family membership; Belongs to the GST superfamily. (198 aa)    
Predicted Functional Partners:
sspB
Putative stringent starvation protein B. Homology to sspB of E. coli of 38% (sprot|SSPB_ECOLI) Seems to act in concert with sspA in the regulation of several proteins during exponential and stationary-phase growth. The exact function of sspB is not yet known. Pfam: Stringent starvation protein B no signal peptide no TMHs.
 
  
 0.983
rpoD
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 
 0.885
rpoA
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.867
rpoC
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
   0.862
rpoB
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.855
rpoZ
DNA-directed RNA polymerase; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.852
lysS
Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS); High confidence in function and specificity; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
  0.802
azo2485
Conserved hypothetical protein. Homology to eca2717 of E. carotovora of 35% (tremble:Q6D3M7). no domains predicted. no signal peptide. no TMHs.
   
  0.802
leuS
Leucine--tRNA ligase; Unnamed protein product; Region start changed from 3544790 to 3544922 (-132 bases); Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 0.779
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
   
  0.772
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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