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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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gene co-occurrence
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[Homology]
Score
hemAHemA protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (417 aa)    
Predicted Functional Partners:
hemL
Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (GSA-AT). TIGRFAM: hemL: glutamate-1-semialdehyde-21-ami; High confidence in function and specificity.
 
 0.993
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.982
gltX2
Glutamate-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
   
 
 0.958
cobA2
Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family.
 
 
 0.938
hemB
Porphobilinogen synthase; Delta-aminolevulinic acid dehydratase chloroplast precursor (ALADH) (ALAD). InterPro: Delta-aminolevulinic acid dehydratase; High confidence in function and specificity; Belongs to the ALAD family.
 
  
 0.873
gcvP
Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.871
hemD
HemD protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.827
prfA
Peptide chain release factor; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.803
gluQ
Glutamate-tRNA ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
     
 0.768
cobA1
Uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). CATALYZES BOTH METHYLATIONS AT C-2 AND C-7 OF UROGEN III LEADING TO PRECORRIN-1 AND PRECORRIN-2; THEIR OXIDATIVE ESTERIFICATION GIVES RESPECTIVELY FACTOR I OCTAMETHYL ESTER AND SIROHYDROCHLORIN (BY SIMILARITY). dph5: diphthine synthase; High confidence in function and specificity.
 
  
 0.756
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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