STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcEProbable glycolate oxidase subunit GlcE. Homology to glcE of E. coli of 47% (sprot|GLCE_ECOLI) InterPro: FAD linked oxidase N-terminal (IPR006093) Pfam: FAD binding domain Tigrfam: glcD: glycolate oxidase subunit GlcD no singla peptide no TMHs; High confidence in function and specificity. (353 aa)    
Predicted Functional Partners:
glcD1
Probable glycolate oxidase subunit glcD. Homology to glcD of E. coli of 64% (sprot|GLCD_ECOLI) InterPro: FAD linked oxidase C-terminal (IPR004113); FAD linked oxidase N-terminal (IPR006093) Pfam: FAD binding domain; FAD linked oxidase, C-terminal domain Tigrfam: glcD: glycolate oxidase subunit GlcD no signal peptide no TMHs; High confidence in function and specificity.
 
 0.995
glcF
Probable glycolate oxidase iron-sulfur subunit. Homology to glcF of E. coli of 56% (sprot|GLCF_ECOLI) Pfam: Domain of unknown function (DUF224) (192-256 aa; 329-391 aa) no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.995
azo0826
Glycerate dehydrogenase (EC 1.1.1.29) (NADH-dependent hydroxypyruvate reductase) (HPR) (GDH) (Hydroxypyruvate dehydrogenase) (Glyoxylate reductase) (HPR-A). PLAYS A CENTRAL ROLE IN ASSIMILATION OF CARBON. IT CONVERTS HYDROXYPYRUVATE TO GLYCERATE AS A KEY STEP IN THE SERINE CYCLE AND MAY ALSO PLAY AN IMPORTANT ROLE IN C2 REACTIONS BY INTERCONVERTING GLYOXYLATE AND GLYCOLATE; Specificity unclear.
   
 0.907
aceA
AceA protein; Isocitrate lyase. Homology to aceA of E. coli of 73% (sprot|ACEA_ECOLI). Isocitrate lyase is an enzyme that catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. InterPro: Isocitrate lyase (IPR000918) Pfam: Isocitrate lyase family no signal peptide no TMHs; High confidence in function and specificity.
     
 0.893
azo1615
TREMBL:Q7VSFO: Probable hydrolase, 55% identity,63% similarity Phosphoglycolate phosphatase (PGP). InterPro:PR006402; HAD-SF-IA-v3. IPR006439; HAD_SF_A_v1. IPR005834; Hydrolase. Pfam:PF00702; Hydrolase; Haloacid dehaloginase like hydrolase TIGRFAMs:TIGR01549; HAD-SF-IA-v1; TIGR01509; HAD-SF-IA-v3; serB: phosphoserine phosphatase SerB hstdl_phs_rel: histidinol phosphatase-; Function unclear.
    
 0.893
cbbZ
Probable phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
    
 0.893
azo3768
Putative catalase; Serves to protect cells from the toxic effects of hydrogen peroxide.
   
 0.870
aceB
AceB protein; Malate synthase. Homology to aceB of A. eutropus of 73% (trembl|Q8VM95). CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + glyoxylate = S-malate + CoA. Acts in the glyoxylate bypass. Pfam: Malate synthase no TMHs 1 HTH; High confidence in function and specificity.
  
 
 0.868
dld
D-lactate dehydrogenase. Homology to dld of Mus musculus of 52% (trembl|Q8CIV4) CATALYZE THE STEREOSPECIFIC OXIDATION OF D-LACTATE TO PYRUVATE. InterPro: FAD linked oxidase C-terminal (IPR004113); FAD linked oxidase, N-terminal (IPR006093) Pfam: FAD binding damian; FAD linked oxidases, C-terminal domain Tigrfam: glcD: glycolate oxidase subunit GlcD no signal peptide no TMHs; Family membership.
 
0.794
hoxF
Probable hydrogen dehydrogenase, alpha subunit. Homology to hoxF of A. eutrophus of 41% (sprot|HOXF_ALCEU). SUBUNITS ALPHA AND GAMMA OF HOXS CONSTITUTE AN NADH-OXIDOREDUCTASE. InterPro: Respiratory-chain NADH dehydrogenase 51 Kd subunit (IPR001949); Respiratory-chain NADH dehydrogenase 24 Kd subunit (IPR002023) Pfam: Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit no signal peptide no TMHs; High confidence in function and specificity.
   
   0.757
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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