pntB protein (Azoarcus sp. BH72) - STRING interaction network

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pntB

Probable NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (459 aa)

Predicted Functional Partners:

pntAA

0.999

pntAB

0.999

ppnK

0.930

nadE

0.910

nadD

0.856

npd2

0.855

azo1006

0.517

azo1311

0.505

azo3712

0.505

lpdA

0.499

Your Current Organism:

Azoarcus sp. BH72

NCBI taxonomy Id: 62928
Other names: A. sp. BH72

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
azo1006	pntAA	azo1006	azo1003	Hypothetical secreted protein. No homology to the data bank. No domains predicted. No TMHs. Signal peptide present.	Probable NAD(P) transhydrogenase, subunit alpha part 1. Homology to pntAA of R. rubrum of 44% (sprot\|PNAA_RHORU). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Tirfam: pntA: NAD(P) transhydrogenase alpha subunit Pfam: Alanine dehydrogenase/pyridine nucleotide dehydrogenase no signal peptide no TMHs; High confidence in function and specificity.	0.498
azo1006	pntAB	azo1006	azo1004	Hypothetical secreted protein. No homology to the data bank. No domains predicted. No TMHs. Signal peptide present.	Conserved hypothetical NAD(P) transhydrogenase,subunit alpha part 2. Homology to pntA of X. axonopodis of 74% (trembl\|Q8PNW6). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 3 TMHs no signal peptide; High confidence in function and specificity.	0.517
azo1006	pntB	azo1006	azo1005	Hypothetical secreted protein. No homology to the data bank. No domains predicted. No TMHs. Signal peptide present.	Probable NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.517
azo1311	azo3712	azo1311	azo3712	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	0.505
azo1311	nadD	azo1311	azo3607	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.511
azo1311	nadE	azo1311	azo1360	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.830
azo1311	pntAA	azo1311	azo1003	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Probable NAD(P) transhydrogenase, subunit alpha part 1. Homology to pntAA of R. rubrum of 44% (sprot\|PNAA_RHORU). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Tirfam: pntA: NAD(P) transhydrogenase alpha subunit Pfam: Alanine dehydrogenase/pyridine nucleotide dehydrogenase no signal peptide no TMHs; High confidence in function and specificity.	0.420
azo1311	pntAB	azo1311	azo1004	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Conserved hypothetical NAD(P) transhydrogenase,subunit alpha part 2. Homology to pntA of X. axonopodis of 74% (trembl\|Q8PNW6). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 3 TMHs no signal peptide; High confidence in function and specificity.	0.420
azo1311	pntB	azo1311	azo1005	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Probable NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.505
azo1311	ppnK	azo1311	azo2580	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.505
azo3712	azo1311	azo3712	azo1311	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Conserved hypothetical protein Has 2 PF05488 PAAR motif(IPR008727);This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins; Function unclear.	0.505
azo3712	lpdA	azo3712	azo1371	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Dihydrolipoamide dehydrogenase. Homology to lpdA of N. meningitides of 70% (trembl\|Q59099). THE BRANCHED-CHAIN ALPHA-KETO DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF ALPHA-KETO ACIDS TO ACYL-COA AND CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE (E1) LIPOAMIDE ACYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) (BY SIMILARITY). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327); Pyridine nucleotide-disulphide oxidoreductase, classI (IPR001100); biotin/Lipoyl attachment (IPR000089) [...]	0.426
azo3712	nadD	azo3712	azo3607	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.544
azo3712	nadE	azo3712	azo1360	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.846
azo3712	npd2	azo3712	azo3660	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	NAD-dependent deacetylase 2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2). Modulates the activities of several enzymes which are inactive in their acetylated form. Similar to SWISSPROT: sprot\|NPD2_PSEAE (50% Pseudomonas aeruginosa, Npd2) / sprot\|NPD1_ARCFU (33% Archaeoglobus fulgidus, NpdA) InterPro: IPR003000 SIR2. Pfam: PF02146 Sir2 family; High confidence in function and specificity.	0.536
azo3712	pntAA	azo3712	azo1003	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Probable NAD(P) transhydrogenase, subunit alpha part 1. Homology to pntAA of R. rubrum of 44% (sprot\|PNAA_RHORU). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Tirfam: pntA: NAD(P) transhydrogenase alpha subunit Pfam: Alanine dehydrogenase/pyridine nucleotide dehydrogenase no signal peptide no TMHs; High confidence in function and specificity.	0.505
azo3712	pntAB	azo3712	azo1004	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Conserved hypothetical NAD(P) transhydrogenase,subunit alpha part 2. Homology to pntA of X. axonopodis of 74% (trembl\|Q8PNW6). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 3 TMHs no signal peptide; High confidence in function and specificity.	0.505
azo3712	pntB	azo3712	azo1005	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Probable NAD(P) transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.505
azo3712	ppnK	azo3712	azo2580	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.510
lpdA	azo3712	azo1371	azo3712	Dihydrolipoamide dehydrogenase. Homology to lpdA of N. meningitides of 70% (trembl\|Q59099). THE BRANCHED-CHAIN ALPHA-KETO DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF ALPHA-KETO ACIDS TO ACYL-COA AND CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE (E1) LIPOAMIDE ACYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) (BY SIMILARITY). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327); Pyridine nucleotide-disulphide oxidoreductase, classI (IPR001100); biotin/Lipoyl attachment (IPR000089) [...]	Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi\|46132577\|ref\|ZP_00171131.2\|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.	0.426

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