STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ispBOctaprenyl-diphosphate synthase; Polyprenyl synthetase,82% identity to TrEMBL;Q5P1Y1. Has Pfam;PF00348, Polyprenyl synthetase.(IPR000092,Polyprenyl_synt)A variety of isoprenoid compounds are synthesized by various organisms. For example in eukaryotes the isoprenoid biosynthetic pathway is responsible for the synthesis of a variety of end products including cholesterol, dolichol, ubiquinone or coenzyme Q. In bacteria this pathway leads to the synthesis of isopentenyl tRNA, isoprenoid quinones, and sugar carrier lipids. Among the enzymes that participate in that pathway, are a number of [...] (341 aa)    
Predicted Functional Partners:
uppS
Probable undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
 
 0.962
ispA
Geranyltranstransferase; Geranylgeranyl pyrophosphate synthetase chloroplast precursor (GGPP synthetase) (GGPS) [Includes: Dimethylallyltransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10); Farnesyltranstransferase (EC 2.5.1.29)]. catalyzes the trans-addition of the three molecules of ipp onto dmapp to form geranylgeranyl pyrophosphate. InterPro: Polyprenyl synthetase; High confidence in function and specificity; Belongs to the FPP/GGPP synthase family.
  
 
0.952
crtB2
Putative phytoene synthase. Homology to crtB of Synechococcus sp. of 35% (SWISSPROT:CRTB_SYNP7 Is involved in the synthesis of carotenoids. Catalyzes the reaction from prephytoene diphosphate to phytoene. Pfam: Squalene/phytoene synthase no singal peptide no TMHs; Family membership.
  
 0.937
ubiA
4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
 
 0.928
menA
Probable 14-dihydroxy-2-naphthoate octaprenyltransferase (EC 2.5.1.-) (DHNA-octaprenyltransferase). CONVERSION OF 1,4-DIHYDROXY-2-NAPHTHOATE (DHNA) TO DIMETHYLMENAQUINONE (DMK). ATTACHES OCTAPRENYLPYROPHOSPHATE A MEMBRANE-BOUND 40-CARBON SIDE CHAIN TO DHNA. THE CONVERSION OF DHNA TO DMK PROCEEDS IN THREE STAGES: THE REMOVAL OF THE CARBOXYL GROUP OF DHNA AS CO2 THE ATTACHMENT OF THE ISOPRENOID SIDE CHAIN AND A QUINOL-TO-QUINONE OXIDATION WHICH IS THOUGHT TO BE SPONTANEOUS (BY SIMILARITY). TIGRFAM: menA: 14-dihydroxy-2-naphthoate octaprenyltransferase; Specificity unclear.
    
 0.925
azo3595
Hypothetical protein predicted by Glimmer/Critica.
  
 0.856
coq7
Ubiquinone biosynthesis protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
    
 0.759
ubiG
3-demethylubiquinone-9 3-O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
  
 
 0.753
ubiH
Probable 2-octaprenyl-6-methoxyphenol hydroxylase oxidoreductase protein; ubiH; aromatic-ring hydroxylase (flavoprotein monooxygenase) Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone. Ubiquinone biosynthesis pathway, by similarity; High confidence in function and specificity.
  
 
 0.731
rplF
50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
  
 
  0.728
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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