Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
asdAsd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. (366 aa)    
Predicted Functional Partners:
lysC
Aspartate kinase (AK) catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine. Similar to trembl|Q8RU02 (80%) and to pir|C83531 (74%). Pfam (PF00696): Amino acid kinase family Pfam (PF01842): two ACT domain; High confidence in function and specificity; Belongs to the aspartokinase family.
 
 
 0.993
hom
Homoserine dehydrogenase catalyzes NAD-dependent reduction of aspartate beta-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. Similar to TREMBL:Q9RAM9 (77%) and to pir|DEPSHA(PIR (Georgetown University) (56%). Pfam: Homoserine dehydrogenase; High confidence in function and specificity.
 
 0.992
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
 
 0.969
azo3485
Conserved hypothetical iron-sulfur binding protein. Homology to pb1470 of B. pertussis of 48% (trembl|Q7VY84). Transfer of electrons in a wide variety of metabolic reactions. InterPro: 4Fe-4S ferredoxin iron-sulfur binding domain (IPR001450). Pfam: 4Fe-4S binding domain. no signal peptide. no TMHs; Family membership.
     
  0.867
pgk
Phosphoglycerate kinaseis an enzyme that catalyses the formation of ATP to ADP and viceversa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate,forming one molecule of ATP. If the reverse were to occur,one molecule of ADP would be formed. 59% PGK. Pfam:PF00162; PGK; 1; High confidence in function and specificity.
  
 0.778
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
  
 0.765
aroE
AroE protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 
 0.732
ilvN
Acetolactate synthase isozyme I small subunit (EC 2.2.1.6) (AHAS-I) (Acetohydroxy-acid synthase I small subunit) (ALS-I). InterPro: Acetolactate synthase small subunit acolac_sm: acetolactate synthase small subunit; High confidence in function and specificity.
  
 
 0.727
icmF
Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
    
 0.694
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
  
  
 0.683
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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