Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
folCDihydrofolate synthase / Tetrahydrofolylpolyglutamate synthase; FolC bifunctional protein [Includes: Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS); Dihydrofolate synthase (EC 6.3.2.12)]. Conversion of folates to polyglutamate derivatives; High confidence in function and specificity. (432 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase (EC 2.5.1.15) (DHPS) (Dihydropteroate pyrophosphorylase). DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity); High confidence in function and specificity.
 
 0.997
folA
FolA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.949
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.903
azo1051
Conserved hypothetical membrane proteine. Homology to BB2598 of Bordetella bronchiseptica of 37% (trembl|Q7WJA1(SRS)). Has 2 copies of PF05036, Sporulation related repeat;IPR007730, SPOR; This 35 residue repeat is found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM. This repeat might be involved in binding peptidoglycan (Bateman A pers obs). FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats [...]
  
    0.889
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK). InterPro: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase Pfam:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; High confidence in function and specificity.
 
 
 0.876
accD
Probable acetyl-coenzyme A carboxylase carboxyl transferase subunit b; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
  
  
 0.870
folB
FolB protein; Dihydroneopterin aldolase (DHNA). CATALYZES THE CONVERSION OF 78-DIHYDRONEOPTERIN TO 6-HYDROXYMETHYL-78-DIHYDROPTERIN. InterPro: Dihydroneopterin aldolase TIGRFAM: folB_dom: FolB domain; High confidence in function and specificity.
  
 
 0.843
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.838
truA
Pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
   
 0.828
cvpA
Colicin V production protein (dedE protein) (Pur regulon 18 kDa protein). REQUIRED FOR COLICIN V PRODUCTION FROM PLASMID INCFI COLV3-K30. TREMBL:Q82WH7: 29% identity,38% similarity InterPro:IPR003825; Colicin_V. Pfam:PF02674; Colicin_V TIGR00304: conserved hypothetical protei Signal peptide present (Signal P predicted) TMH's 4 (TMHMM predicted); High confidence in function and specificity.
 
  
 0.820
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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