STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vanB1Probable vanillate O-demethylase oxidoreductase (Vanillate degradation ferredoxin-like protein). Homology to vanB of P. sp HR199 of 40% (sprot|VANB_PSEUH). The vanillate demethylase (EC:1.14.13.82) consists of two proteins: an oxygenase and an oxygenase reductase (VanA and VanB). This enzyme is involved in the vanillate degradation, a key intermediate in the degradation of lignin. InterPro: NADH:cytochrome b5 reductase (CBR)(IPR001834); Ferredoxin (IPR001041); Oxidoreductase FAD and NAD(P) binding domain (IPR001433) Pfam: Oxidoredutase FAD-binding domain; Oxidoreductase NAD-binding dom [...] (315 aa)    
Predicted Functional Partners:
hoxF
Probable hydrogen dehydrogenase, alpha subunit. Homology to hoxF of A. eutrophus of 41% (sprot|HOXF_ALCEU). SUBUNITS ALPHA AND GAMMA OF HOXS CONSTITUTE AN NADH-OXIDOREDUCTASE. InterPro: Respiratory-chain NADH dehydrogenase 51 Kd subunit (IPR001949); Respiratory-chain NADH dehydrogenase 24 Kd subunit (IPR002023) Pfam: Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit no signal peptide no TMHs; High confidence in function and specificity.
  
 0.965
fdh1B
Probable formate dehydrogenase (NADP+), beta subunit Homology to fdh1B of M. extorpuens of 55% (trembl|Q8KTI8) Pfam: Respiratory-chain NADH dehydrogenase 24 kD subunit; Respiratory-chain NADH dehydrogenase 51 kD subunit. no signal peptide no TMHs; High confidence in function and specificity.
  
 0.965
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 0.946
carBb1
Putative dioxygenase hydroxylase large component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation. 81% simialr to a Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBb. Involved in the aerobic degradation of carbazole by Pseudomonas resinovorans sp. strain CA10. TREMBL:Q8GI28 InterPro:IPR005806; Rieske_reg.IPR001663; Ring_hydroxyl_A. Pfam:PF00355; Rieske; 1. PF00848; Ring_hydroxyl_A; [...]
 
 
 0.944
carBa1
Putative dioxygenase, hydroxylase small component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. The beta subunit is may be responsible for the substrate specificity of the enzyme. Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBa. Involved in the aerobic degradation of carbazole by P.resinovorans sp. strain CA10. XlyY: Benzene 12-dioxygenase beta subunit (EC 1.14.12.3), involved in benzoate degradation.Degradation of benzoate to 2-hydro-12-dihydroxybenzoate (dhb).; Conserved hypotheti [...]
 
 
 0.936
azo2527
Cytochrome P450s are involved in the oxidative degradation of various compounds. Particularly well known for their role in the degradation of environmental toxins and mutagens. Similar to SWISSPROT:P77902 (30% identity); TREMBL:Q59910 (32% identity); SWISSPROT:O34374 (28% identity). Pfam (PF00067): Cytochrome P450; Family membership.
 0.936
paaB
Phenylacetic acid degradation protein PaaB; May be part of a multicomponent oxygenase involved in phenylacetyl-coa hydroxylation. Phenylacetic acid aerobic catabolism pathway, TREMBL:Q8XS76 (75% identity); SWISSPROT:P76078 (61% identity); High confidence in function and specificity.
  
 
 0.882
abmA
2-amninobenzoyl-CoA monooxygenase/reductase (EC 1.14.13.40) Homology to abmA of A. evansii of 86% (trembl|Q93FB8(SRS). natural fusion protein of a monooxygenase and a reductase; contains flavin. Pfam: Monooxygnease; NADH:flavin oxidoreductase/NADH oxidorecutase. no signal peptide. no TMHs; High confidence in function and specificity.
    
 0.865
boxA
Benzoyl-CoA oxygenase component A. 84% 4Fe4S_ferredoxin. IPR001709; FPN_cyt_redctse. IPR001433; Oxred_FAD/NAD(P). Pfam:PF00037; Fer4; 2. PF00175; NAD_binding_1; 1; High confidence in function and specificity.
  
 0.846
paaA
Phenylacetic acid degradation protein [paaA],86% identity(91% similarity) to TrEMBL;Q9F9U9. 72% identity to TrEMBL;Q7WGX6, Q8XS77 Has PF05138, Phenylacetic acid catabolic protein;IPR007814, PaaA_PaaC; This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex. No Signal Peptide or TMH present; High confidence in function and specificity.
  
 0.807
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.