STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceK[Isocitrate dehydrogenase (NADP+)] kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (589 aa)    
Predicted Functional Partners:
icd1
Isocitrate dehydrogenase [NADP]. Homology to icd1 of A. eutropus of 75% (trembl|Q8KLU5) Isocitrate dehydrogenase is an important enzyme of the TCA which catalyzes the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+ Pfam: Isocitrate/isopropylmalate dehydrogenase Tigrfam: prok_nadp_idh: isocitrate dehydrogenase no signal peptide no TMHs; High confidence in function and specificity.
 
 
 
 0.950
aceA
AceA protein; Isocitrate lyase. Homology to aceA of E. coli of 73% (sprot|ACEA_ECOLI). Isocitrate lyase is an enzyme that catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. InterPro: Isocitrate lyase (IPR000918) Pfam: Isocitrate lyase family no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.889
aceB
AceB protein; Malate synthase. Homology to aceB of A. eutropus of 73% (trembl|Q8VM95). CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + glyoxylate = S-malate + CoA. Acts in the glyoxylate bypass. Pfam: Malate synthase no TMHs 1 HTH; High confidence in function and specificity.
 
  
 0.530
azo3439
Conserved hypothetical protein. Homology to ebB122 of Azoarcus sp. EbN1 of 65% (gnl|keqq|eba:ebB122(KEGG)). No domains predicted. NO signal peptide present. No TMH present.
  
     0.456
putA
Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
      
 0.414
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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