STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gipHydroxypyruvate isomerase (EC 5.3.1.22).Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).Belongs to the hyi family. 52%; High confidence in function and specificity. (262 aa)    
Predicted Functional Partners:
glxR1
Putative 2-hydroxy-3-oxopropionate reductase Homology to glxR of E. coli of 39% (SWISSPROT:GLXR_ECOLI) Activity:- (R)-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H. InterPro: 3-hydroyisobutyrate dehydrogenase (IPR002204) Pfam: Nad binding domain of 6-phosphoglucanate dehydrogenase (PF03446) Tigrfam: gnd_rel: 6-phosphoglucante no signal peptide no TMHs; Family membership.
 
 0.947
azo0826
Glycerate dehydrogenase (EC 1.1.1.29) (NADH-dependent hydroxypyruvate reductase) (HPR) (GDH) (Hydroxypyruvate dehydrogenase) (Glyoxylate reductase) (HPR-A). PLAYS A CENTRAL ROLE IN ASSIMILATION OF CARBON. IT CONVERTS HYDROXYPYRUVATE TO GLYCERATE AS A KEY STEP IN THE SERINE CYCLE AND MAY ALSO PLAY AN IMPORTANT ROLE IN C2 REACTIONS BY INTERCONVERTING GLYOXYLATE AND GLYCOLATE; Specificity unclear.
   
 
 0.898
ttuD
Putative hydroxypyruvate reductase. Degrades an unidentified toxic product from the first step of tartrate degradation. Involved in the second step of the tartrate degradation pathway. 59% MOFRL.IPR005346; UPF0125. Pfam:PF05161; MOFRL; 1.PF03658; UPF0125; 1. Signal peptide present; High confidence in function and specificity.
 
   
 0.846
glxR2
Probable 2-hydroxy-3-oxopropionate reductase Homology to glxR of E. coli of 46% (SWISSPROT:GLXR_ECOLI) Activity:- (R)-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H. InterPro: 3-hydroyisobutyrate dehydrogenase (IPR002204) Pfam: Nad binding domain of 6-phosphoglucanate dehydrogenase (PF03446) Tigrfam: gnd_rel: 6-phosphoglucante no signal peptide no TMHs 0; High confidence in function and specificity.
 
 0.832
azo3591
Sugar or sugar nucleotide oxidoreductase; Family membership.
    
  0.532
serA
D-3-phosphoglycerate dehydrogenase, SerA, is involved in the pathway of serine biosynthesis. Similar to sprot|SERA_ECOLI (61%). InterPro (PF00389): D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain InterPro (PF01842): ACT domain InterPro (PF02826): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity.
    
  0.501
mmsB
Putative 3-hydroxyisobutyrate dehydrogenase; Activity:- 3-hydroxy-2-methylpropanoate + NAD = 2-methyl-3-oxopropanoate + NADH2 Entry name SWISSPROT:MMSB_PSEAE InterPro IPR002204; 3hydroxisobut_dh. IPR006115; 6PGD_NAD. Pfam PF03446; NAD_binding_2; 1. Identities = 48/218 (22%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
  
 
 0.495
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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