| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aas | azo1194 | azo0150 | azo1194 | AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...] | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | 0.492 |
| aas | azo1783 | azo0150 | azo1783 | AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...] | Conserved hypothetical membrane protein. Homology to ebA6946 of Azoarcus sp. EbN1 of 64% (gnl|keqq|eba:ebA6946(KEGG)). Pfam: Pospholipase D, active site motife; DedA family. no signal peptide. 6 TMHs; Conserved hypothetical protein. | 0.913 |
| aas | pabB | azo0150 | azo0198 | AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...] | Para-aminobenzoate synthase component I (EC 4.1.3.-) (ADC synthase). CATALYZES THE BIOSYNTHESIS OF 4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND GLUTAMINE. InterPro: Anthranilate synthase component I and chorismate binding enzyme pabB: para-aminobenzoate synthase component I; Specificity unclear. | 0.658 |
| aas | pheA | azo0150 | azo1068 | AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...] | Bifunctional chorismate mutase/prephenate dehydratase P-protein, pheA,; High confidence in function and specificity. | 0.483 |
| argM | azo1194 | azo1195 | azo1194 | Probable acetylornithine transaminase. Homology to argM of E. coli of 45% (sprot|ARGM_ECOLI). Catalyzes the transmination of n(2)-succinylornithine and alpha-ketoglutarate into n(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase. Tigrfam: argD: acetylornithine and succinylornithine aminotransferases Pfam: Aminotransferse class-III no TMHs; High confidence in function and specificity. | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | 0.588 |
| asd | azo1194 | azo1042 | azo1194 | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | 0.505 |
| asd | hom | azo1042 | azo2081 | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | Homoserine dehydrogenase catalyzes NAD-dependent reduction of aspartate beta-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. Similar to TREMBL:Q9RAM9 (77%) and to pir|DEPSHA(PIR (Georgetown University) (56%). Pfam: Homoserine dehydrogenase; High confidence in function and specificity. | 0.992 |
| asd | metH | azo1042 | azo3726 | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.605 |
| asd | pabB | azo1042 | azo0198 | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | Para-aminobenzoate synthase component I (EC 4.1.3.-) (ADC synthase). CATALYZES THE BIOSYNTHESIS OF 4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND GLUTAMINE. InterPro: Anthranilate synthase component I and chorismate binding enzyme pabB: para-aminobenzoate synthase component I; Specificity unclear. | 0.613 |
| asd | pheA | azo1042 | azo1068 | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | Bifunctional chorismate mutase/prephenate dehydratase P-protein, pheA,; High confidence in function and specificity. | 0.624 |
| azo0835 | azo1194 | azo0835 | azo1194 | Membrane fusion protein; The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family,; Family membership. | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | 0.564 |
| azo0835 | hylD | azo0835 | azo0647 | Membrane fusion protein; The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family,; Family membership. | Putative HylD family secretion protein. Homology to hylD of E. coli of 24% (sprot|HLY4_ECOLI) Involved in the transport of hemolysin A. InterPro: HlyD family secretion protein; Gram-negative bacteril RTX secretion protein D Pfam: HylD family secretion protein no signal peptide no TMHs; Family membership. | 0.544 |
| azo1194 | aas | azo1194 | azo0150 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...] | 0.492 |
| azo1194 | argM | azo1194 | azo1195 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Probable acetylornithine transaminase. Homology to argM of E. coli of 45% (sprot|ARGM_ECOLI). Catalyzes the transmination of n(2)-succinylornithine and alpha-ketoglutarate into n(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase. Tigrfam: argD: acetylornithine and succinylornithine aminotransferases Pfam: Aminotransferse class-III no TMHs; High confidence in function and specificity. | 0.588 |
| azo1194 | asd | azo1194 | azo1042 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity. | 0.505 |
| azo1194 | azo0835 | azo1194 | azo0835 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Membrane fusion protein; The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family,; Family membership. | 0.564 |
| azo1194 | azo1783 | azo1194 | azo1783 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Conserved hypothetical membrane protein. Homology to ebA6946 of Azoarcus sp. EbN1 of 64% (gnl|keqq|eba:ebA6946(KEGG)). Pfam: Pospholipase D, active site motife; DedA family. no signal peptide. 6 TMHs; Conserved hypothetical protein. | 0.488 |
| azo1194 | hom | azo1194 | azo2081 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Homoserine dehydrogenase catalyzes NAD-dependent reduction of aspartate beta-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. Similar to TREMBL:Q9RAM9 (77%) and to pir|DEPSHA(PIR (Georgetown University) (56%). Pfam: Homoserine dehydrogenase; High confidence in function and specificity. | 0.526 |
| azo1194 | hylD | azo1194 | azo0647 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Putative HylD family secretion protein. Homology to hylD of E. coli of 24% (sprot|HLY4_ECOLI) Involved in the transport of hemolysin A. InterPro: HlyD family secretion protein; Gram-negative bacteril RTX secretion protein D Pfam: HylD family secretion protein no signal peptide no TMHs; Family membership. | 0.564 |
| azo1194 | metH | azo1194 | azo3726 | Putative integral membrane efflux protein; Permease member of the Major Facilitator Superfamiliy (MFS)transporters. MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. 2A0121: H+ Antiporter protein 24% similarity to NorA who confer relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus. 20% similarity to TapA a multidrug efflux pump wich confers low level of resistance to aminoglycosides and tetracycline in Mycobaterium fortuitum and M. [...] | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.529 |
