STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
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[Homology]
Score
argMProbable acetylornithine transaminase. Homology to argM of E. coli of 45% (sprot|ARGM_ECOLI). Catalyzes the transmination of n(2)-succinylornithine and alpha-ketoglutarate into n(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase. Tigrfam: argD: acetylornithine and succinylornithine aminotransferases Pfam: Aminotransferse class-III no TMHs; High confidence in function and specificity. (392 aa)    
Predicted Functional Partners:
argJ
Probable arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
 
 0.989
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
 
 
 0.987
dapD
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. Homology to dapD of E. coli of 74% (sprot|DAPD_ECOLI). Involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde. Catalytic activity: succinyl-coa + (r)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + h(2)o = coa + (r)-2-(succinylamino)-6- oxoheptanedioate. InterPro: Bacterial transferase hexapeptide repeat (IPR001451) no signal peptide no TMH; High confidence in function and specificity.
    
 0.934
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
    
 0.933
argA
Amino-acid N-acetyltransferases acting mainly on glutamate in the first step of the 'acetylated' ornithine biosynthesis pathway. For this reason it is also called N-acetylglutamate synthase. The enzyme may also act on aspartate. Similar to sprot|ARGA_YERPE (44%) and to sprot|ARGA_ECOLI (43%). Pfam (PF00696): Aspartokinase superfamily Pfam (PF00583): GCN5-related N-acetyltransferase; Specificity unclear.
 
 
 0.929
argB
ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 
 0.899
argF
ArgF protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
 0.889
argH
ArgH protein; Argininosuccinate lyase (EC 4.3.2.1) (Arginosuccinase) (ASAL); High confidence in function and specificity.
 
  
 0.872
argG
ArgG protein; Argininosuccinate synthase, argG. Similar to SWISSPROT:ASSY_NITEU (81%). Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. InterPro (PF00764): Argininosuccinate synthase InterPro (TIGR00032): Argininosuccinate synthase; High confidence in function and specificity.
 
 
 0.862
dapC
N-succinyldiaminopimelate aminotransferase, DapC converting N-succinyl-2-amino-6-ketopimelate, the product of the succinylase DapD, to N-succinyl-L,L-DAP, the substrate of the desuccinylase DapE. Similar to trembl|Q8XZK1 (63%) and to pir|F83189 (57%). Pfam: Aminotransferase, class I and II; Specificity unclear.
    
 0.857
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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