node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
azo0455 | folE2 | azo0455 | azo1197 | Putative cobalmin snthesis protein; This family of proteins contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [1]. TREMBL:Q8YJP6: 40% identity, 54% similarity. Pfam:PF02492; Cobalmine synthesis protein; pfkB family carbohydrate kinase; FAD binding domain. TIGRFAM:proC: pyrroline 5 carboxylate reductase. mobB: molybdopterin-guanine dinucleotide; Family membership. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.692 |
azo1196 | dxs | azo1196 | azo1198 | Conserved hypothetical protein. Homology to ypo3484 of y. pestis of 60% (trembl|Q8ZBD2). Pfam: Luciferase-like monooxygenase. no signla peptide no TMHs. | Probable 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.547 |
azo1196 | folE2 | azo1196 | azo1197 | Conserved hypothetical protein. Homology to ypo3484 of y. pestis of 60% (trembl|Q8ZBD2). Pfam: Luciferase-like monooxygenase. no signla peptide no TMHs. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.773 |
azo1210 | folE2 | azo1210 | azo1197 | Putative GTPase; TREMBLnew:CAE26305: 46% identity, 65% similarity. sprot:YJIA_ECOLI, 33% identity, 55% similarity Hypothetical protein. Pfam:cobW: Cobalmine synthesis protein; ABC_tran TIGRFAM: MMR_HSR1- GTPASE of unknown function InterPro: Cobalamin synthesis protein/P47K mobB: molybdopterin-guanine dinucleotid; Conserved hypothetical protein. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.692 |
azo2482 | barA | azo2482 | azo2402 | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | Putative sensor-regulator protein,; Specificity unclear. | 0.998 |
azo2482 | folE | azo2482 | azo2133 | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity. | 0.914 |
azo2482 | folE2 | azo2482 | azo1197 | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.676 |
azo2482 | pykA | azo2482 | azo2842 | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | Pyruvate kinase (PK) catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP:ADP + phosphoenolpyruvate = ATP + pyruvate. 52% Pyruvate_kinase. Pfam:PF00224; PK; 1.PF02887; PK_C; 1. TIGRFAMs:TIGR01064; pyruv_kin; 1; High confidence in function and specificity. | 0.920 |
azo2482 | ribAB | azo2482 | azo0319 | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.941 |
azo3118 | folE | azo3118 | azo2133 | Lyase, putative 6-pyruvoyl tetrahydrobiopterin synthase protein InterPro: 6-pyruvoyl tetrahydropterin synthase TIGRFAM: 6PTHBS: 6-pyruvoyl tetrahydrobiopterin synthase; Specificity unclear. | FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity. | 0.973 |
azo3118 | folE2 | azo3118 | azo1197 | Lyase, putative 6-pyruvoyl tetrahydrobiopterin synthase protein InterPro: 6-pyruvoyl tetrahydropterin synthase TIGRFAM: 6PTHBS: 6-pyruvoyl tetrahydrobiopterin synthase; Specificity unclear. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.957 |
barA | azo2482 | azo2402 | azo2482 | Putative sensor-regulator protein,; Specificity unclear. | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | 0.998 |
barA | folE | azo2402 | azo2133 | Putative sensor-regulator protein,; Specificity unclear. | FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity. | 0.914 |
barA | folE2 | azo2402 | azo1197 | Putative sensor-regulator protein,; Specificity unclear. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.676 |
barA | pykA | azo2402 | azo2842 | Putative sensor-regulator protein,; Specificity unclear. | Pyruvate kinase (PK) catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP:ADP + phosphoenolpyruvate = ATP + pyruvate. 52% Pyruvate_kinase. Pfam:PF00224; PK; 1.PF02887; PK_C; 1. TIGRFAMs:TIGR01064; pyruv_kin; 1; High confidence in function and specificity. | 0.920 |
barA | ribAB | azo2402 | azo0319 | Putative sensor-regulator protein,; Specificity unclear. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.941 |
dxs | azo1196 | azo1198 | azo1196 | Probable 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Conserved hypothetical protein. Homology to ypo3484 of y. pestis of 60% (trembl|Q8ZBD2). Pfam: Luciferase-like monooxygenase. no signla peptide no TMHs. | 0.547 |
dxs | folE2 | azo1198 | azo1197 | Probable 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.680 |
dxs | ribAB | azo1198 | azo0319 | Probable 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.535 |
folE | azo2482 | azo2133 | azo2482 | FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity. | Putative hybrid sensor and regulator; Gene function unknown, no significant homology to proteins of known function. Typical domains for hybrid sensor and regulator are found. InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR001789 Response_reg. IPR008207 Hpt. IPR000014 PAS_domain. IPR001610 PAC. Pfam: PF00072 Response_reg. PF02518 HATPase_c. PF00512 HisKA. PF00989 PAS. PF00785 PAC. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00448 REC. SM00091 PAS SM00086 PAC. TIGRFAM: TIGR00229 PAS domain S-box. Signal P reporting signal pepti [...] | 0.914 |