STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1221Conserved hypothetical aromatic/alkene monooxygenase, subunit beta Homology to blr3679 of B. japonicum of 53% (trembl|Q89P04(SRS) Bacterial aromatic/alkene monooxygenase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives (like methane and toulene). Interpro: Methane/Penol/Toluene hydroxylase (IPR003430) Pfam: Methane/Penol/Toluene hydroxylase (PF02332) no signal peptide no TMHs; Specificity unclear. (363 aa)    
Predicted Functional Partners:
azo1219
Conserved hypothetical aromatic/alkene monooxygenase, subunit alpha Homology to blr3677 of B. japonicum (trembl|Q89P06(SRS) Bacterial aromatic/alkene monooxygenase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives (like methane and toulene). InterPro:IPR003430 Pfam: Methane/Phenol/Toluene hydroxylase (PF02332) no signal peptide no TMHs; Specificity unclear.
 
 
 0.989
dmpM
Phenol hydroxylase P2 protein (Phenol 2-monooxygenase P2 component)68% similarity to SWISSPROT:P19731,Pseudomonas sp DmpM or Phenol hydroxylase protein component P2, this protein lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase. Phenol hydroxylase catabolises phenol and some of its methylated derivatives in the first step of phenol biodegradation, and is required for growth on phenol. The multicomponent enzyme is made up of P0, P1, P2, P3, P4 and P5 polypeptides. Pfam:PF02406, InterPro:IPR003454 91% similarity with hypothetical protein Rgel01002820 [Rub [...]
 
 
  0.959
azo1220
Conserved hypothetical aromatic/alkene monooxygenase, subunit gamma. Homology to blr3678 of B. japonicum of 60% (trembl|Q89P05(SRS) Bacterial aromatic/alkene monooxygenase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives (like methane and toulene). Interpro: Phenol hydroxylase reductase family (IPR001221); Oxidoredutase FAD and NAD(P)-binding domain (IPR000134); NADH:cytochrome b5 reductase (CBR) (IPR000134) Pfam: 2Fe-2S iron-sulfur cluster binding domain; oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain no signal peptide no [...]
 
  
  0.944
lapN
Phenol 2-monooxygenase p3 component,; High confidence in function and specificity.
 
 
 0.919
poxD
Probable phenol hydroxylase subunit,68% identity(84% similarity) to trEMBL:Q9RAF6,Phenol hydroxylase component [phyC] [Ralstonia sp. KN1]. TrEMBL;Q9ZNP4 Has PF02332:Methane/Phenol/Toluene Hydroxylase;IPR003430;Bacterial phenol hydroxylase (EC: 1.14.13.7) is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This family contains both the P1 and P3 polypeptides of phenol hydroxlase and the alpha and beta chain of methane hydroxylase protein A. Methane hydroxylase protein A (EC: 1.14.13.25) is responsible for the initial oxygenation of methane to metha [...]
 
 
 0.914
poxF
Probable phenol hydroxylase (EC 1.14.13.7) (Phenol 2-monooxygenase P5 component). Probable electron transfer from NADPH via FAD and the 2Fe-2S center to the oxygenase activity site of the enzyme. InterPro: Oxidoreductase FAD and NAD(P)-binding domain hisT_truA: tRNA pseudouridine synthase A; Specificity unclear.
 
  
  0.850
lapP
Phenol hydroxylase P5 protein (EC 1.14.13.7) (Phenol 2-monooxygenase P5 component). Probable electron transfer from NADPH via FAD and the 2Fe-2S center to the oxygenase activity site of the enzyme; High confidence in function and specificity.
 
  
  0.844
ascD
Probable CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase. Homology to ascD of Y. pestis of 41% (sprot|ASCD_YERPE). PARTICIPATES IN THE CONVERSION OF CDP-6-DEOXY-D-GLYCERO- L-THREO-4-HEXULOSE TO 36-DIDEOXY-D-GLYCERO-D-GLYCERO-4-HEXULOSE TOGETHER WITH CDP-6-DEOXY-D-GLYCERO-L-THREO-4-HEXULOSE-3-DEHYDRASE (E1) IN TWO CONSECUTIVE STEPS. THE DETAILED MECHANISM OF E3 IS NOT YET RESOLVED. InterPro: Oxidoreductase FAD and NAD(P)-binding domain (IPR001433); NadH:cytochrome b5 reductase (CBR) (IPR000134); 2Fe-2S Ferredoxin (IPR006057); Phenol hydroylase reductase family (IPR001221) [...]
 
  
  0.818
lapM
Phenol 2-monooxygenase p2 component,; High confidence in function and specificity.
 
 
  0.805
oxoR
Reductase component OxoR, of the 2-oxo-1,2-dihydroquinoline 8 monooxygenase protein. Enzyme involved in the second step of quinoline degradation by P. putida 86. Involved in bacterial aromatic compounds degradation; High confidence in function and specificity.
 
  
 0.802
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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