| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alr | azo1244 | azo3925 | azo1244 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | 0.796 |
| alr | ddlB | azo3925 | azo0886 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Probable D-alanine-D-alanine ligase; Cell wall formation. | 0.950 |
| alr | polA | azo3925 | azo3600 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.438 |
| azo1243 | azo1244 | azo1243 | azo1244 | Conserved hypothetical N-acetylmuramoyl-L-alanine amidase. Homology to amiC of R. solanaceraum of 50% (trembl|Q8XWD5) CELL-WALL HYDROLASE PROBABLY INVOLVED IN CELL-WALL HYDROLYSIS SEPTATION OR RECYCLING (BY SIMILARITY). Pfam: N-acetylmuramoyl-L-alanine amidase no signal peptide no TMHs; Family membership. | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | 0.864 |
| azo1243 | nnrD | azo1243 | azo2076 | Conserved hypothetical N-acetylmuramoyl-L-alanine amidase. Homology to amiC of R. solanaceraum of 50% (trembl|Q8XWD5) CELL-WALL HYDROLASE PROBABLY INVOLVED IN CELL-WALL HYDROLYSIS SEPTATION OR RECYCLING (BY SIMILARITY). Pfam: N-acetylmuramoyl-L-alanine amidase no signal peptide no TMHs; Family membership. | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] | 0.489 |
| azo1243 | queG | azo1243 | azo1245 | Conserved hypothetical N-acetylmuramoyl-L-alanine amidase. Homology to amiC of R. solanaceraum of 50% (trembl|Q8XWD5) CELL-WALL HYDROLASE PROBABLY INVOLVED IN CELL-WALL HYDROLYSIS SEPTATION OR RECYCLING (BY SIMILARITY). Pfam: N-acetylmuramoyl-L-alanine amidase no signal peptide no TMHs; Family membership. | Conserved hypothetical electron transport protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.641 |
| azo1244 | alr | azo1244 | azo3925 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.796 |
| azo1244 | azo1243 | azo1244 | azo1243 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Conserved hypothetical N-acetylmuramoyl-L-alanine amidase. Homology to amiC of R. solanaceraum of 50% (trembl|Q8XWD5) CELL-WALL HYDROLASE PROBABLY INVOLVED IN CELL-WALL HYDROLYSIS SEPTATION OR RECYCLING (BY SIMILARITY). Pfam: N-acetylmuramoyl-L-alanine amidase no signal peptide no TMHs; Family membership. | 0.864 |
| azo1244 | azo1711 | azo1244 | azo1711 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Conserved hypothetical glycoprotease. Homology to yeaZ of N. europae of 41% (trembl|Q82US9). InterPro: Glycoprotease (M22) metallo-protease family (IPR000905). Tigrfam: gcp: metalloendopeptidase putative glycoprotease family. Pfam: Glyocprotease family. no signal peptide. no TMHs; Family membership. | 0.990 |
| azo1244 | azo2888 | azo1244 | azo2888 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Conserved hypothetical protein. Homology to ne0191 of N. europaea of 61% (trembl|Q82XR3). Pfam: DUF227. no signal peptide. no TMHs. | 0.560 |
| azo1244 | ddlB | azo1244 | azo0886 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Probable D-alanine-D-alanine ligase; Cell wall formation. | 0.549 |
| azo1244 | gcp | azo1244 | azo3224 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Probable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.954 |
| azo1244 | miaA | azo1244 | azo3131 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | MiaA protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.562 |
| azo1244 | nnrD | azo1244 | azo2076 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] | 0.854 |
| azo1244 | polA | azo1244 | azo3600 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.597 |
| azo1244 | queG | azo1244 | azo1245 | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | Conserved hypothetical electron transport protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.675 |
| azo1711 | azo1244 | azo1711 | azo1244 | Conserved hypothetical glycoprotease. Homology to yeaZ of N. europae of 41% (trembl|Q82US9). InterPro: Glycoprotease (M22) metallo-protease family (IPR000905). Tigrfam: gcp: metalloendopeptidase putative glycoprotease family. Pfam: Glyocprotease family. no signal peptide. no TMHs; Family membership. | Conserved hypothetical protein having uncharacterised P-loop hydrolase, 47% Identity to TrEMBL;Q82WL4,Q63WN1. Has PF02367, Uncharacterised P-loop hydrolase UPF0079;IPR003442; This signature is found in a family of bacterial proteins, which contain a P-loop. | 0.990 |
| azo1711 | gcp | azo1711 | azo3224 | Conserved hypothetical glycoprotease. Homology to yeaZ of N. europae of 41% (trembl|Q82US9). InterPro: Glycoprotease (M22) metallo-protease family (IPR000905). Tigrfam: gcp: metalloendopeptidase putative glycoprotease family. Pfam: Glyocprotease family. no signal peptide. no TMHs; Family membership. | Probable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.973 |
| azo1711 | miaA | azo1711 | azo3131 | Conserved hypothetical glycoprotease. Homology to yeaZ of N. europae of 41% (trembl|Q82US9). InterPro: Glycoprotease (M22) metallo-protease family (IPR000905). Tigrfam: gcp: metalloendopeptidase putative glycoprotease family. Pfam: Glyocprotease family. no signal peptide. no TMHs; Family membership. | MiaA protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.417 |
| azo1711 | nnrD | azo1711 | azo2076 | Conserved hypothetical glycoprotease. Homology to yeaZ of N. europae of 41% (trembl|Q82US9). InterPro: Glycoprotease (M22) metallo-protease family (IPR000905). Tigrfam: gcp: metalloendopeptidase putative glycoprotease family. Pfam: Glyocprotease family. no signal peptide. no TMHs; Family membership. | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...] | 0.445 |