STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1292Adenylate cyclase; Conserved hypothetical protein,40% identity to TrEMBL;Q88AR4 Has PF01928|CYTH domain(IPR008172);These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Has PF05235:CHAD domain(IPR007899);The CHAD domain is an alpha-helical domain functionally associated with the CYTH domains. It has conserved histidines that may chelate metals. (497 aa)    
Predicted Functional Partners:
sixA
Putative phosphohistidine phosphatase, SixA. TIGRFAM: TIGR00249; sixA. Phosphohistidine phosphatase sixA (EC 3.1.3.-) (RX6). EXHIBITS PHOSPHOHISTIDINE PHOSPHATASE ACTIVITY TOWARDS THE HPT DOMAIN OF THE ARCB SENSOR INVOLVED IN THE MULTISTEP HIS- ASP PHOSPHORELAY; Specificity unclear.
 
     0.744
ribAB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.735
glnE
Probable [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the si [...]
       0.701
azo3620
Putative adenylate/ guanylate cyclase,; Function unclear.
  
  
  0.611
azo0484
FHA domain containing protein. Best similarity to SWISSPROT: sprot|REPB_AGRRH (9% Agrobacterium rhizogenes,possible replication protein b) Pfam: PF00211 Adenylate and Guanylate cyclase catalytic domain. SMART: SM00240 FHA Forkhead associated domain.
  
  
  0.602
azo2450
Putative two-component system sensor protein,; Function unclear.
    
 0.536
azo1290
Conserved hypothetical protein. Homology to ebA98 of Azoarcus sp. EbN1 of 67% (gnl|keqq|eba:ebA983(KEGG)). No domains predicted. No signal peptide. No TMHs.
 
     0.477
ppx
Putative exopolyphosphatase; 45% Ppx_GppA. Pfam:PF02541; Ppx-GppA; 1; High confidence in function and specificity.
    
  0.475
azo3685
Putative hybrid sensor and regulator protein, MmoS) InterPro: IPR003594; ATPbind_ATPase. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR008207; Hpt. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. IPR001789; Response_reg. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00785; PAC. PF00989; PAS. PF00072; Response_reg. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00073; HPT. SM00086; PAC. SM00091; PAS. SM00448; REC. TIGRFAM: TIGR00229; sensory_box. TMHMM reporting 2 transmembrane helices; Family membership.
     
 0.458
azo1817
Conserved hypothetical two-component hybrid sensor and regulator. Homology to ebA6890 of Azoarcus sp. EbN1 of 56% (gnl|keqq|eba:ebA6890(KEGG)). InterPro: IPR003594 ATPbind_ATPase. IPR004358 Bact_sens_pr_C. IPR005467 His_kinase. IPR003661 His_kinA_N. IPR009082 His_kin_homodim. IPR001610 PAC. IPR000700 PAS-assoc_C. IPR000014 PAS_domain. IPR001789 Response_reg. Pfam: PF02518 HATPase_c. PF00512 HisKA. PF00785 PAC. PF00989 PAS. PF00072 Response_reg. SMART: SM00387 HATPase_c. SM00388 HisKA. SM00086 PAC. SM00091 PAS. SM00448 REC. TIGRFAM: TIGR00229 sensory_box; 3 TMHMM reporting 7 transmembra [...]
     
 0.450
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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