Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
tldDProbable TldD protein. Homology to tldD of E. coli of 59% (sprot|TLDD_ECOLI). Suppresses the inhibitory activity of the carbon storage regulator (csrA). Pfam: putative modulator of DNA gyrase no signal peptide no TMHs; Function unclear. (481 aa)    
Predicted Functional Partners:
pmbA
Probable PmbA protein. Homology to pmbA of E. coli of 48% (sprot|PMBA_ECOLI). MAY FACILITATE THE SECRETION OF THE PEPTIDE ANTIBIOTIC MICROCIN B17 (MCCB17) BY COMPLETING ITS MATURATION. SUPPRESSES THE INHIBITORY ACTIVITY OF THE CARBON STORAGE REGULATOR (CSRA). Pfam: Putative modulator of DNA gyrase no signal peptide no TMHs; High confidence in function and specificity.
 
 
0.912
azo1294
Conserved hypothetical protein. Homology to cv2096 of C. violaceum of 32% (trembl|Q7NW94(SRS) no domains predicted no signal peptide 1 TMHs.
 
   
 0.720
azo1295
Conserved hypothetical carbon-nitrogen hydrolase. Homolog to bb1933 of B. bronchiseptica (trembl|Q7WL17). InterPro: Carbon-nitrogen hydrolase (IPR003010) Pfam: Carbon-nitorgen hydrolase no signal peptide no TMHs; Conserved hypothetical protein.
  
    0.677
glnE
Probable [glutamate-ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the si [...]
  
    0.551
coaE
CoaE protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
      0.539
fumB
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.534
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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