STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cblHTH-type transcriptional regulator cbl (Cys regulon transcriptional activator) Belongs to the LysR family of transcriptional regulators. THIS PROTEIN IS A POSITIVE REGULATOR OF GENE EXPRESSION FOR THE CYSTEINE REGULON. THE INDUCER FOR CYSB IS N-ACETYLSERINE (BY SIMILARITY). ribD_Cterm: riboflavin-specific deami 55% similarity to the HTH-type transcriptional regulator cbl, E. coli SWISSPROT:CBL_ECOLI IPR000847; HTH_LysR. IPR005119; LysR_subst. PF00126; HTH_1; 1. helix-turn-helix PF03466; LysR_substrate; 1. HTH reporting nucleic acid binding motif; High confidence in function and specificity. (311 aa)    
Predicted Functional Partners:
cysA
Putative sulfate transport ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
 
     0.820
cysW
Sulfate transport system permease protein cysW. Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane. InterPro: Binding-protein-dependent transport systems inner membrane component uppS: undecaprenyl diphosphate synthase; High confidence in function and specificity.
 
     0.802
cysT
Sulfate transport system permease protein probably; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
       0.776
cysP
Putative sulfate transport system substrate-binding protein; CysP: sulfate/thiosulfate periplasmic binding protein. Sulfate-binding protein precursor (Sulfate starvation-induced protein 2) (SSI2). This protein specifically binds sulfate and is involved in its transmembrane transport. mazG: MazG family protein; High confidence in function and specificity.
       0.772
azo1247
Transcriptional regulator, LysR family This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression. 29% 1 helixturnhelix PF03466 LysR_substrate; 1. HTH reporting nucleic acid binding motif; Specificity unclear.
  
     0.514
aapM
Putative amino-acid ABC transporter permease. Homology to aapM of R. leguminosarum of 38% (sprot|AAPM_RHILV) PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM YDHWXYZ FOR AN AMINO ACID; PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. Pfam: binding-protein-dependent transport system signal peptide probable 8 TMHs; Family membership.
       0.499
aapQ
Putative amino acid permease. Homology to aapQ of R. leguminosarum of 35% (sprot|AAPQ_RHILVast). PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR L-AMINO ACIDS. AFFECTS THE UPTAKE AS WELL AS EFFLUX OF THESE AMINO ACIDS. PROBABLY RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. InterPro: Binding-protein-dependent transport systems inner membrane component (IPR000515) Pfam: Binding-protein -dependent transport system 1 HTH no signal peptide probable 4 TMHs; Family membership.
       0.499
aapJ
Putative amino acid ABC transporter periplasmic binding protein. Homology to aapJ of R. leguminosarum of 52% (sprot|AAPJ_RHILV). PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR L-AMINO ACIDS AFFECTS THE UPTAKE AS WELL AS EFFLUX OF THESE AMINO ACIDS. InterPro: Bacterial extracellular solute-binding proteins family 3 (IPR001638); solute binding protein/glutamate receptor (IPR001311) Pfam: Bacterial extracellular solute-binding proteins signal peptide no TMHs TIGR00045: conserved hypothetical prote; High confidence in function and specificity.
       0.499
azo1636
HTH-type transcriptional regulator,; Family membership; Belongs to the LysR transcriptional regulatory family.
  
     0.498
ampR
Probable transcriptional regulator, LysR family; Probable HTH-type transcriptional activator ampR. Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (ampC) in the presence of beta-lactams and induces it in the absence of them. Similar to SWISSPROT: sprot|AMPR_PSEAE (34% Pseudomonas aeruginosa,HTH-type transcriptional activator AmpR) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.490
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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