STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccoIPutative cation-transporting ATPase; 36% ATPase-IB1_Cu.IPR006416; ATPase-IB_hvy.IPR001757; ATPase_E1-E2.IPR005834; Dehal_like_hydro.IPR008250; E1-E2_ATPase_reg. IPR006121; HeavyMe_transpt.IPR000695; H_ATPase.IPR006191; Metal_bind. Pfam:PF00122; E1-E2_ATPase; 1.PF00403; HMA; 1.PF00702; Hydrolase; 1. TMHs:8; Specificity unclear. (827 aa)    
Predicted Functional Partners:
copZ
Conserved hypothetical copper chaperon. Homology to copZ of copZ Azoarcus sp. EbN1 of 66%. Pfam: Heavy-metal-associated domain. Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures. Tigrfam: TIGR00003: copper-ion-binding protein. No signal peptide. No TMHs; Conserved hypothetical protein.
 
 
 0.944
ccoS
Conserved hypothetical cytochrome oxidase maturation protein. Homology to cco of P.Putida of 42% (gnl|keqq|ppu:PP4262(KEGG)). Pfam: Cytochrome oxidase maturation protein cbb3-type. Genes encoding a cytochrome cbb3 oxidase were initially designated fixNOQP (ccoNOQP),the ccoNOQP operon is always found close to a second gene cluster, known as fixGHIS (ccoGHIS) whose expression is necessary for the assembly of a functional cbb3 oxidase. On the basis of their derived amino acid sequences each of the four proteins encoded by the ccoGHIS operon are thought to be membrane-bound. It has been su [...]
 
  
 0.942
ccoP
Probable cytochrome c oxidase, cbb3-type,subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
 
   
 0.814
ccoO
Probable cytochrome c oxidase, cbb3-type, subunit II Homology to ccoO of P. stutzeri of 58% (trembl|Q8KS21). CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1- 3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. CO I IS THE CATALYTIC SUBUNIT OF THE ENZYME. ELECTRONS ORIGINATING IN CYTOCHROME C OR A QUINOL ARE TRANSFERRED TO THE BIMETALLIC CENTER FORMED BY A HIGH-SPIN HEME AND COPPER B. Tigrfam: ccoO: cytochrome c oxidase cbb3-type, subunit II Pfam: Cytochrome c oxidase, mono-heme subunit no signal peptide probable 1 [...]
 
   
 0.792
ccoN
Probable cytochrome c oxidase, cbb3-type, subunit I. Homology to ccoN of R. capsulatus of 62% (sprot|COX1_RHOCA). CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1- 3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. CO I IS THE CATALYTIC SUBUNIT OF THE ENZYME. ELECTRONS ORIGINATING IN CYTOCHROME C OR A QUINOL ARE TRANSFERRED TO THE BIMETALLIC CENTER FORMED BY A HIGH-SPIN HEME AND COPPER B. Tigrfam: ccoN: cytochrome c oxidase cbb3-type Pfam: cytochrome c and quinol oxidase polyppeptide no signal peptide 12 TMHs; Hig [...]
 
   
 0.791
ccoG
Putative iron-sulfur 4Fe-4S ferredoxin transmembrane protein. Homology to fixG of R. meliloti of 36% (FIXG_RHIME). Ferredoxins are iron-sulphur proteins that mediate electron transfer in a range of metabolic reactions; they fall into several subgroups according to the nature of their iron-sulphur cluster(s). One group,originally found in bacteria, has been termed ''bacterial-type'', in which the active centre is a 4Fe-4S cluster. 4Fe-4S ferredoxins may in turn be subdivided into further groups, based on their sequence properties. Most contain at least one conserved domain, including fo [...]
 
   
 0.741
azo1353
Conserved hypothetical membrane protein. Homology to ebA5153 of Azoarcus sp. EbN1 of 79% (gnl|keqq|eba:ebA5153(KEGG)). Has PF02683;Cytochrome C biogenesis protein transmembrane region (IPR003834 Ctytoch_TM): This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family. No signal peptide. 5 TMHs; Conserved hypothetical protein.
 
   
 0.706
ccoH
Conserved hypothetical membrane protein. Homology to ebA5136 Azoarcus sp. EbN1 of 51% (gnl|keqq|eba:ebA5136(KEGG)). Has PF05751, FixH;IPR008620; This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG. No signal peptide predicted. 1 TMHs; Conserved hypothetical protein.
 
  
 0.658
rdxB
Putative iron-sulfur 4Fe-4S ferredoxin transmembrane protein. Homology to rdxB of R. sphaeroides of 39% (sprot|RDXB_RHOSH). Involved in a membrane generated redox signal; required to maintain repression of photosynthesis gene expression in the presence of oxygen. InterPro: 4Fe-4S ferredoxin iron-sulfur binding domain (IPR001450) Pfam: 4Fe-4S binding doamin no signal peptide probable 5 TMHs; Family membership.
 
   
 0.650
rdxA
Putative iron-sulfur 4Fe-4S ferredoxin transmembrane protein. Homology to rdxA of R. sphaeroides of 37% (SWISSPROT:RDXA_RHOSH) Involved in a membrane generated redox signal. Pfam: 4Fe-4S binding domain Probable 5 TMHs no signal peptide; Family membership.
 
   
 0.645
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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