Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lolAPutative outer membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (225 aa)    
Predicted Functional Partners:
lolB
Conserved hypothetical outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
 
 
 0.920
FtsK
Putative cell division protein; DNA translocase ftsK 2. InterPro: FtsK/SpoIIIE family; High confidence in function and specificity.
  
  
 0.869
lolE1
Putative lipoprotein transporter, permease protein. Homology to lolE of E. coli of 36% (sprot|LOLE_ECOLI). Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of lolA (By similarity). Pfam: Predicted permease signal peptide 3 TMHs; High confidence in function and specificity.
 
 
 
 0.847
azo1367
Hypothetical protein CBU1189. InterPro: AAA-protein (ATPases associated with various cellular activities) ruvB: Holliday junction DNA helicase R; Specificity unclear.
  
    0.820
lolD
Lipoprotein releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
   
 
 0.782
azo1882
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q89X55 (42% identity); SWISSPROT:P31219 (40% identity). InterPro (IPR003439): ABC transporter. InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). Pfam (PF00005): ABC trans [...]
   
 
 0.781
azo1362
Hypothetical protein. no homology of the entire protein with the data bank. Pfam: Smr domain InterPro: Smr domain This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2. no signal peptide no TMHs.
 
     0.727
oma
Outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
   
 0.703
ostA
Organic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
  
   
 0.692
azo0056
Conserved hypothetical membrane protein. Homology to cv3942 of C. violaceum of 30% (trembl|Q7NR42) InterPro: DUF214 (IPR003838) Pfam: Predicted permease This is a family of predicted permeases and hypothetical transmembrane proteins. One member has been shown to transport lipids targeted to the outer membrane across the inner membrane, a step which requires ATP. Signal peptide 3 TMHs; Conserved hypothetical protein.
   
 
 0.665
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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