STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pdhAPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (893 aa)    
Predicted Functional Partners:
lpdA
Dihydrolipoamide dehydrogenase. Homology to lpdA of N. meningitides of 70% (trembl|Q59099). THE BRANCHED-CHAIN ALPHA-KETO DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF ALPHA-KETO ACIDS TO ACYL-COA AND CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE (E1) LIPOAMIDE ACYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3) (BY SIMILARITY). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327); Pyridine nucleotide-disulphide oxidoreductase, classI (IPR001100); biotin/Lipoyl attachment (IPR000089) [...]
 
 0.999
pdhB
Probable dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.998
odhL
Probable dihydrolipoamide dehydrogenase. Homology to odhL of A. eutrophus of 68% (sprot|DLDH_ALCEU). THE BRANCHED-CHAIN ALPHA-KETO DEHYDROGENASE COMPLEX CATALYZES THE OVERALL CONVERSION OF ALPHA-KETO ACIDS TO ACYL-COA AND CO(2). IT CONTAINS MULTIPLE COPIES OF 3 ENZYMATIC COMPONENTS: BRANCHED-CHAIN ALPHA-KETO ACID DECARBOXYLASE (E1) LIPOAMIDE ACYLTRANSFERASE (E2) AND LIPOAMIDE DEHYDROGENASE (E3). InterPro: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR001327); Pyridine nucleotide-disulphide oxidoreductase, classI (IPR001100); Pyridine nucleotide-disulphide oxidoreducta [...]
 
 
 0.986
azo3870
Hypothetical protein. Homology of the entire orf to the C-terminus of dihydrolipoamide acetyltransferase. Pfam: 2-0xo acid dehydrogenase acyltransferase no TMHs no signal peptide.
  
 0.968
maeB1
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40) (NADP-ME). Homology to dme of S. meliloti of 60% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. Tigrfam: pta: phosphotransacetylase Pfam: Malic enzyme; Phosphate acetyl/butaryltransferase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.945
maeB2
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). Homology to dme of S. meliloti of 61% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. InterPro: Phosphate acetyl/butaryl transferase (IPR002505); Malic enzyme (IPR001891) Pfam: Malic enzyme; Phosphate acetyl/butaryl transferase Tigrfam: pta: phosphotransacetylase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.945
odhB
Dihydrolipoamide S-succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.944
pykA
Pyruvate kinase (PK) catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP:ADP + phosphoenolpyruvate = ATP + pyruvate. 52% Pyruvate_kinase. Pfam:PF00224; PK; 1.PF02887; PK_C; 1. TIGRFAMs:TIGR01064; pyruv_kin; 1; High confidence in function and specificity.
  
 
 0.944
pgi
Glucose-6-phosphate isomerase 1(EC 5.3.1.9) (GPI 1)(Phosphoglucose isomerase 1)(PGI 1)(Phosphohexose isomerase 1) (PHI 1). Enzyme involved in glycolysis and in gluconeogenesis.Catalytic activity: d-glucose 6-phosphate = d-fructose 6- phosphate.Belongs to the gpi family. 39% G6P_Isomerase. Pfam:PF00342; PGI; 1; High confidence in function and specificity.
  
 
 0.939
ppsA1
Putative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.937
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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