STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
pfkAPutative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (421 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase 1(EC 5.3.1.9) (GPI 1)(Phosphoglucose isomerase 1)(PGI 1)(Phosphohexose isomerase 1) (PHI 1). Enzyme involved in glycolysis and in gluconeogenesis.Catalytic activity: d-glucose 6-phosphate = d-fructose 6- phosphate.Belongs to the gpi family. 39% G6P_Isomerase. Pfam:PF00342; PGI; 1; High confidence in function and specificity.
  
 0.996
fba
Putative fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.983
cbbF
Putative fructose-1,6-bisphosphatase; Fructose-16-bisphosphatase cytosolic(D-fructose-16-bisphosphate 1-phosphohydrolase) (FBPase).Involved in the reaction: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate., 62% In_FB_phphtase. Pfam:PF00316; FBPase; 1; High confidence in function and specificity.
    
 0.965
tkt
Putative transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
    
 0.957
xanB
Probable xanthan biosynthesis protein XanB. Homology to xanB of X. campestris of 60% (sprot|XANB_XANCP(SRS)) Xanthan biosynthesis protein XanB is a multifunctional enzyme including Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphomannose isomerase) (PMI) (Phosphohexomutase)and Mannose-1-phosphate guanylyl transferase (GDP) (EC 2.7.7.22) (GDP-mannose pyrophosphorylase) (GMP). InterPro: ADP-glucose pyrophosphorylase (IPR005835); Mannose-6-phosphate isomerase type II (IPR001538) Pfam: Nucleotidyl transferase, Mannose-6-phosphate isomerase no signal peptide no TMHs; Family membership.
    
 0.946
pykA
Pyruvate kinase (PK) catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP:ADP + phosphoenolpyruvate = ATP + pyruvate. 52% Pyruvate_kinase. Pfam:PF00224; PK; 1.PF02887; PK_C; 1. TIGRFAMs:TIGR01064; pyruv_kin; 1; High confidence in function and specificity.
 
 
 0.938
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.935
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.910
tim
Putative triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
 0.875
tal
Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
    
 0.815
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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