Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dusCConserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (366 aa)    
Predicted Functional Partners:
yggH
tRNA (guanine-N(7)-)-methyltransferase, 29% identity to SwissProt;Q8EBX8. SwissProt;Q8Y1I7(25% Identity),Q8FE22(25% identity). Has PF02390,Methyltransf_4,Putative methyltransferase;IPR003358; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.
  
 
 0.800
azo1524
Conserved hypothetical protein. Homology to ct227 of C. tepidum of 32% (trembl|Q8KA93). Pfam: SEC-C motif This motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain. no TMHs.
 
     0.743
azo1525
Conserved hypothetical protein. Homology to PA3209 of Pseudomonas aeruginosa of 43% (trembl:Q9HZ31). Has PF03692, Uncharacterised protein family (UPF0153); IPR005358;This family of proteins contain 8 conserved cysteines that may form a metal binding site. The function of these proteins is unknown but might be an Fe-S cluster as part of an oxidoreductase complex. No signal peptide. No TMHs.
       0.700
azo1526
Probable Ferredoxin; TREMBL:Q8XH16: 56% identity, 66% similarity. SPROT:P71300: 53% identity, 67% similarity Hypothetical protein ykgJ; This family of proteins contain 8 conserved cysteines that may form a zinc binding site. The function of these proteins is unknown InterPro:IPR005358; UPF0153. Pfam: PF03692; UPF0153 No signal peptide. No transmembrane helices; High confidence in function and specificity.
       0.608
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
       0.592
adhC
Alcohol dehydrogenase class III (Formaldehyde dehydrogenase (glutathione)). Homology to fdh of E. coli of 72% (trembl|Q59399) CLASS-III ADH IS REMARKABLY INEFFECTIVE IN OXIDIZING ETHANOL BUT IT READILY CATALYZES THE OXIDATION OF LONG-CHAIN PRIMARY ALOCHOLS AND THE OXIDATION OF S-(HYDROXYMETHYL) GLUTATHIONE (BY SIMILARITY). InterPro: Zinc-containing alcohol dehydrogenase superfamily (IPR002085) Zinc-containing alcohol dehydrogenase (IPR002328) Pfam: zinc-binding dehydrogenase Tigrfam: tdh: L-threonine 3-dehydrogenase. no signal peptide. 2 TMHs; High confidence in function and specificity.
    
   0.552
truA
Pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
 
 0.517
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.499
metG
MetG protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.498
trmA
tRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
 
  
 0.493
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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