STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
dusCConserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (366 aa)    
Predicted Functional Partners:
azo2893
Putative fis-like DNA-binding protein, 57% Identity to SwissProt;Q8Y231,TrEMBL;Q7P0M2(58% Identity). Has PF02954, Bacterial regulatory protein, Fis family;IPR002197 HTH_Fis; The Factor for Inversion Stimulation (FIS) protein is a regulator of bacterial functions, and binds specifically to weakly related DNA sequences. It activates ribosomal RNA transcription, and is involved in upstream activation of rRNA promoters. The protein has been shown to play a role in the regulation of virulence factors in both Salmonella typhimurium and Escherichia coli. Some of its functions include inhibiti [...]
  
  
 0.819
yggH
tRNA (guanine-N(7)-)-methyltransferase, 29% identity to SwissProt;Q8EBX8. SwissProt;Q8Y1I7(25% Identity),Q8FE22(25% identity). Has PF02390,Methyltransf_4,Putative methyltransferase;IPR003358; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.
  
 
 0.811
azo1524
Conserved hypothetical protein. Homology to ct227 of C. tepidum of 32% (trembl|Q8KA93). Pfam: SEC-C motif This motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain. no TMHs.
 
     0.744
azo1525
Conserved hypothetical protein. Homology to PA3209 of Pseudomonas aeruginosa of 43% (trembl:Q9HZ31). Has PF03692, Uncharacterised protein family (UPF0153); IPR005358;This family of proteins contain 8 conserved cysteines that may form a metal binding site. The function of these proteins is unknown but might be an Fe-S cluster as part of an oxidoreductase complex. No signal peptide. No TMHs.
       0.698
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
  
 
 0.637
azo1526
Probable Ferredoxin; TREMBL:Q8XH16: 56% identity, 66% similarity. SPROT:P71300: 53% identity, 67% similarity Hypothetical protein ykgJ; This family of proteins contain 8 conserved cysteines that may form a zinc binding site. The function of these proteins is unknown InterPro:IPR005358; UPF0153. Pfam: PF03692; UPF0153 No signal peptide. No transmembrane helices; High confidence in function and specificity.
       0.606
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
       0.589
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
    0.553
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.487
trmA
tRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
 
  
 0.463
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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