STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
citEProbable Citrate lyase beta chain(EC 4.1.3.6)(Citrase)(Citryl-CoA lyase subunit)(EC 4.1.3.34). In citrate-utilising prokaryotes, citrate lyase cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha,beta, and gamma subunits.The alpha subunit substitutes citryl for the acetyl group to form citryl-S-ACP. The beta subunit completes the reaction by cleaving the citryl to yield oxaloacetate and (regenerated) acetyl-S-ACP. Similar to the CitE protein from L.mesenteroides where is part of a gene cluster citCDEFG. SWISSPROT:CILB [...] (331 aa)    
Predicted Functional Partners:
fumB
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.870
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.831
maeB1
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40) (NADP-ME). Homology to dme of S. meliloti of 60% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. Tigrfam: pta: phosphotransacetylase Pfam: Malic enzyme; Phosphate acetyl/butaryltransferase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.790
maeB2
Probable malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). Homology to dme of S. meliloti of 61% (sprot|MAO1_RHIME). Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. InterPro: Phosphate acetyl/butaryl transferase (IPR002505); Malic enzyme (IPR001891) Pfam: Malic enzyme; Phosphate acetyl/butaryl transferase Tigrfam: pta: phosphotransacetylase no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.790
azo1995
Conserved hypothetical protein; 41% Aldolase_II_N. Class II Aldolase and Adducin N-terminal domain Pfam: PF00596; Aldolase_II; 1. fucA: L-fuculose phosphate aldolase; High confidence in function and specificity.
   
    0.782
azo2608
Conserved hypothetical protein; 42% Aldolase_II_N.Class II Aldolase and Adducin N-terminal domain. Pfam: PF00596; Aldolase_II; 1. TIGR: PP2871; High confidence in function and specificity.
   
    0.782
fucA
L-fuculose phosphate aldolase(L-fuculose-1-phosphate aldolase). Involved in the fucose metabolism catalyzing the third step of the pathway, L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. 41% Aldolase_II_N.IPR004782; FucA. Pfam:PF00596; Aldolase_II; 1. TIGRFAMs:TIGR01086; fucA; 1; High confidence in function and specificity.
   
    0.782
pta
Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 
 0.736
icmF
Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
 
   
 0.681
gltA
Probable citrate synthase. Homology to gltA of s. meliloti of 69% (sprot|CISY_RHIME). Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle: Citrate + CoA = acetyl-CoA + H2 O + oxaloacetate InterPro: Citrate synthase (IPR002020) Pfam: Citrate synthase no signal peptide no TMHs; High confidence in function and specificity.
    
 0.654
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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