STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1553Conserved hypothetical protein, 39% identity to Swissprot;Q46825, ygfY of Escherichia coli. Has PF03937:(IPR005631, DUF339)TPR repeat region;This family represents a set of three divergent TPR repeats found in a small group of uncharacterised proteins. No Signal Peptide or TMH present; Family membership. (78 aa)    
Predicted Functional Partners:
sdhA
Probable succinate dehydrogenase, flavoprotein subunit. Homology to sdhA of C. burnetii of 54% (sprot|DHSA_COXBU) Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein,cytochrome b-556 and a hydrophobic protein. CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor. InterPro: Fumarate reductase/succinate dehydrogenase flavoprotein N-terminal (IPR003953); Fumarate reductase/succinate dehydrogenase FAD-binding site (IPR003952); Fumarate reductase/succinate dehydrogenase, C-terminal (IPR004112) Pfam: FAD-binding domain; Fumarate reduct [...]
  
 0.986
sdhB
Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity.
  
 
 0.929
sdhC
Succinate dehydrogenase cytochrome b-556 subunit,sdhC.58% Identity to TrEMBL;Q7NZ57.52% to TrEMBL;Q9JRJ0,36% to SwissProt;P10446. Has PF01127,Succinate dehydrogenase cytochrome b subunit;IPR000701 Sdh_cyt; Succinate dehydrogenase (SDH) is a membrane-bound complex of two main components: a membrane-extrinsic component composed of an FAD-binding flavoprotein and an iron-sulphur protein, and a hydrophobic component composed of a cytochrome b and a membrane anchor protein.The cytochrome b component is a mono heme transmembrane protein belonging to a family that includes cytochrome b-556 fr [...]
 
  
 0.921
sdhD
Succinate dehydrogenase, hydrophobic membrane anchor subunit. Homology to sdhD of C. burnetii of 41% (sprot|DHSD_COXBU). THIS IS THE HYDROPHOBIC COMPONENT OF THE SUCCINATE DEHYDROGENASE COMPLEX. IT IS SUGGESTED THAT IT IS REQUIRED TO ANCHOR THE CATALYTIC COMPONENTS TO THE CYTOPLASMIC MEMBRANE. no signal peptide 3 TMHS; Family membership.
 
  
  0.877
fumB
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.757
gltA
Probable citrate synthase. Homology to gltA of s. meliloti of 69% (sprot|CISY_RHIME). Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle: Citrate + CoA = acetyl-CoA + H2 O + oxaloacetate InterPro: Citrate synthase (IPR002020) Pfam: Citrate synthase no signal peptide no TMHs; High confidence in function and specificity.
    
 0.693
ccoH
Conserved hypothetical membrane protein. Homology to ebA5136 Azoarcus sp. EbN1 of 51% (gnl|keqq|eba:ebA5136(KEGG)). Has PF05751, FixH;IPR008620; This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG. No signal peptide predicted. 1 TMHs; Conserved hypothetical protein.
  
     0.664
azo3757
Modification methylase TaqI (EC 2.1.1.72) (Adenine-specific methyltransferase TaqI) (M.TaqI). THIS METHYLASE RECOGNIZES THE DOUBLE-STRANDED SEQUENCE TCGA CAUSES SPECIFIC METHYLATION ON A-4 ON BOTH STRANDS AND PROTECTS THE DNA FROM CLEAVAGE BY THE TAQI ENDONUCLEASE. InterPro: N6 adenine-specific DNA methyltransferase N12 class; Family membership.
  
     0.656
azo3116
Conserved hypothetical protein. Homology to NMA0336 of N.meningitidis of 59% (trembl:Q9JRG4) Has PF01381 Helix-turn-helix:IPR001387:HTH_3;This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases,various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum. No signal peptide or TMH reported present.
  
     0.652
azo1520
Conserved hypothetical membrane protein. Homology to CV1748 of C. violaceum of 32% (trembl|Q7NX80(SRS)). No domains predicted. No signal peptide 11 TMHs; Conserved hypothetical protein.
  
     0.640
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.