STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1604Conserved hypothetical protein; Transglutaminase-like superfamily domain protein;67% identity (79% similarity) to TrEMBL;Q87VL0. TrEMBL;Q6N3E0(57% identity). Has SMART;SM00460,TGc;Transglutaminase/protease-like homologues: (IPR002931):Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events. NO [...] (1126 aa)    
Predicted Functional Partners:
azo1603
Conserved hypothetical protein,52% Identity to TrEMBL;Q9HUN7. Has PF04169;Domain of unknown function (DUF404);(IPR007297)This is a protein of unknown function. It sometimes occurs in combination with two domains of unknown function DUF403 (IPR007296) and DUF407 (IPR007302). Has PF04174;Domain of unknown function (DUF407);This is a protein of unknown function. It sometimes occurs in combination with two domains of unknown function DUF403 (IPR007296) and DUF404 (IPR007297). Has PF04168;Bacterial domain of unknown function (DUF403);This is a protein of unknown function. It sometimes occur [...]
 
  
 0.965
azo1514
Conserved hypothetical protein. Homology to RS04633 of R.solanacearum of 73% (tremble:Q8Y0C3). Has PF04169(IPR007297);Domain of unknown function (DUF404);This is a protein of unknown function. It sometimes occurs in combination with two domains of unknown function DUF403 (IPR007296) and DUF407 (IPR007302). Has PF04174;Domain of unknown function (DUF407);This is a protein of unknown function. It sometimes occurs in combination with two domains of unknown function DUF403 (IPR007296) and DUF404 (IPR007297). No signal Peptide or TMH present.
 
    0.795
azo1793
Conserved hypothetical protein.Weak Homology with Hits in the Database. Has IPR000967 Znf_NFX1;(SMART;SM00438)This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger: C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C, where X can be any amino acid, and numbers in brackets indicate the number of residues. The two position can be either his or cys. This domain is found in the human transcriptional repressor NK-X1, a repressor of HLA-DRA transcription; the Drosophila shuttle craft protein, which plays an essential role during the late stages of e [...]
 
     0.766
azo1515
Conserved Hypothetical protein, 57% identity to TrEMBL;Q8Y0C2 Has PF04168;(IPR00729)Bacterial domain of unknown function (DUF403):This is a protein of unknown function. It sometimes occurs in combination with two domains of unknown function DUF404 (IPR007297) and DUF407 (IPR007302). No Signal peptide or TMH reported Present; Function unclear.
 
  
 0.762
azo1602
Conserved hypothetical protein. Homology to Rv2569c/MT2645/Mb2599c of M. bovis of 38%. Pfam: Transglutaminase-like superfamily. no signal peptide no TMHs; Specificity unclear.
 
    
0.685
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
  0.668
ruvB
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
     
  0.618
ruvA
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
     
  0.618
rnpA
Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
     
  0.618
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
  0.602
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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