STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
azo1606Putative inner membrane transport permease; Similar to TREMBL:Q7WGZ1 (41% identity); TREMBL:Q7W9R7 (41% identity); TREMBL:Q8XXM2 (37% identity). Pfam (DUF214): Predicted permease. TMHMM reporting 10 transmembrane helices; Specificity unclear. (830 aa)    
Predicted Functional Partners:
tesA1
Probable acyl-CoA thioesterase. Homology to tesA of E. coli of 42% (sprot|TESA_ECOLI) Hydrolyzes long chain acyl thioesters (c12-c18): 2-lysophosphatidylcholine + h(2)o = glycerophosphocholine + a fatty acid anion. InterPro: GDSL lipolytic enzyme (IPR001087) Pfam: Lipase/Acylhydrolase with GDSL-like motif signal peptide no TMH; Family membership.
 
     0.788
hipO2
Hippurate hydrolase (EC 3.5.1.32) (Benzoylglycine amidohydrolase) (Hippuricase). TREMBL:Q7WFU4: 48% identity, 58% similarity InterPro:IPR002933; Peptidase_M20. IPR010168; Pept_M20D_amidh. Pfam: PF01546; Peptidase_M20; 1. TIGRFAMs TIGR01891; amidohydrolases No signal peptide present No transmembrane helices present mreB: cell shape determining protein M; High confidence in function and specificity.
  
    0.768
azo1880
Conserved hypothetical secreted protein. TREMBL:O86370 (36% identity); TREMBL:Q7U0W8 (36% identity). No domains predicted. SignalP reporting signal peptide. No TMHs; Conserved hypothetical protein.
 
  
 0.750
tesA2
Putative acyl-CoA thioesterase. Homology to tesA of E. coli of 32% (sprot|TESA_ECOLI) Hydrolyzes long chain acyl thioesters (c12-c18): 2-lysophosphatidylcholine + h(2)o = glycerophosphocholine + a fatty acid anion. InterPro: GDSL lipolytic enzyme (IPR001087) Pfam: Lipase/Acylhydrolase GDSL-like motif signal peptide no TMH; Family membership.
 
     0.728
macB
ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.706
azo1667
Putative ABC transporter ATP-binding protein; Similar to TREMBL:Q82UM8 (55% identity); TREMBL:Q8XYP0 (59% identity); TREMBL:Q7W685 (59% identity). Pfam (PF00005): ABC transporter; Specificity unclear.
 
     0.619
azo1882
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q89X55 (42% identity); SWISSPROT:P31219 (40% identity). InterPro (IPR003439): ABC transporter. InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). Pfam (PF00005): ABC trans [...]
 
 
 0.520
azo1604
Conserved hypothetical protein; Transglutaminase-like superfamily domain protein;67% identity (79% similarity) to TrEMBL;Q87VL0. TrEMBL;Q6N3E0(57% identity). Has SMART;SM00460,TGc;Transglutaminase/protease-like homologues: (IPR002931):Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events. NO [...]
       0.456
lolD
Lipoprotein releasing system ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
  
 
 0.452
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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