STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kuConserved hypothetical protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (303 aa)    
Predicted Functional Partners:
azo1741
Putative DNA-ligase like protein Rv0938/MT0965. dnl1: DNA ligase I ATP-dependent; Specificity unclear; ORF4.
 
  
 0.986
azo1795
Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear.
 
    0.709
lig2
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]). This protein seals during DNA replication DNA recombination and DNA repair nicks in double-stranded DNA (By similarity); High confidence in function and specificity.
 
  
 0.609
azo1739
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:O32291 (45% identity); SWISSPROT:P54554 (28% identity). Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.
       0.525
azo1832
Conserved hypothetical secreted protein. Homology ebA6930 of Azoarcus EbN1 of 31% (gnl|keqq|eba:ebA6930(KEGG)). No domains predicted. Signal peptide present. No TMH present; Conserved hypothetical protein.
 
     0.478
azo1732
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,; Family membership.
  
     0.472
azo1791
Conserved hypothetical secreted protein. Homology to ebA6930 of Azoarcus sp. EbN1 of 37% (gnl|keqq|eba:ebA6930(KEGG)). No domains predicted. Signal peptide present. No TMH reported present; Conserved hypothetical protein.
 
     0.432
azo0334
Conserved hypothetical secreted protein. Homology to BPP2140 of Bordetella parapertussis 0f 44% (trembl|Q7W8J3(SRS)) No domains predicted. Signal peptide present. No TMH present. 6PTHBS: 6-pyruvoyl tetrahydrobiopterin; Conserved hypothetical protein.
 
     0.421
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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