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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1795Conserved hypothetical protein; DNA topoisomerase I (EC 5.99.1.2). The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. cbiB: cobalamin biosynthesis protein; Specificity unclear. (365 aa)    
Predicted Functional Partners:
azo1791
Conserved hypothetical secreted protein. Homology to ebA6930 of Azoarcus sp. EbN1 of 37% (gnl|keqq|eba:ebA6930(KEGG)). No domains predicted. Signal peptide present. No TMH reported present; Conserved hypothetical protein.
 
     0.914
recQ
ATP-dependent DNA helicase recQ (EC 3.6.1.-). INVOLVED IN THE RECF RECOMBINATION PATHWAY; ITS GENE EXPRESSION IS UNDER THE REGULATION OF THE SOS SYSTEM. IT IS A DNA HELICASE. recq: ATP-dependent DNA helicase RecQ; High confidence in function and specificity.
    
 
 0.898
gyrB
DNA topoisomerase (ATP-hydrolysing); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...]
   
 
 0.892
parE
Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.892
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
    
 
 0.865
azo1792
Conserved hypothetical membrane protein. Homology to xcc0923 of X. campestris of 46% (trembl|Q8PC30). InterPro: Uncharacterized protein family UPF0003 (IPR006685). Pfam: Mechanosensitive ion chanell. Mechanosensitive (MS) channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. no signal peptide. 5 TMHs; Conserved hypothetical protein.
 
     0.862
glgX
Putative glycogen debranching enzyme; Glycogen operon protein GlgX homolog.Hydrolyzes the alpha-1,6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen. 46% Alpha_amyl_cat.IPR004193; Glyco_hydro_13N. Pfam:PF00128; alpha-amylase; 1.F02922; isoamylase_N; 1; High confidence in function and specificity; Belongs to the glycosyl hydrolase 13 family.
 
     0.817
azo1741
Putative DNA-ligase like protein Rv0938/MT0965. dnl1: DNA ligase I ATP-dependent; Specificity unclear; ORF4.
 
 
 
 0.813
azo1793
Conserved hypothetical protein.Weak Homology with Hits in the Database. Has IPR000967 Znf_NFX1;(SMART;SM00438)This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger: C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C, where X can be any amino acid, and numbers in brackets indicate the number of residues. The two position can be either his or cys. This domain is found in the human transcriptional repressor NK-X1, a repressor of HLA-DRA transcription; the Drosophila shuttle craft protein, which plays an essential role during the late stages of e [...]
 
     0.810
glgB2
14-alpha-glucan branching enzyme (Glycogen branching enzyme)(BE) (14-alpha-D-glucan:14-alpha-D-glucan 6-glucosyl- transferase). Catalyzes the formation of the alpha-16-glucosidic linkages in glycogen by scission of a 14-alpha-linked oligosaccharide from growing alpha-14-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-16 position. 36% Alpha_amyl_cat.IPR006407;GlgB.IPR004193;Glyco_hydro_13N. Pfam:PF00128; Alpha-amylase; 1.PF02922; Isoamylase_N; 1. TIGRFAMs:TIGR01515; branching_enzym; 1; High confidence in function and specificity.
  
    0.779
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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