STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
lapB1Catechol 2,3-dioxygenase; In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. The lap genes are located in a 13.2 kb region with 14 ORFs in the order lapRBKLMNOPCEHIFG and with the same transcriptional orientation. Catechol 2,3-dioxygenase LapB,; High confidence in function and specificity. (311 aa)    
Predicted Functional Partners:
lapK
Phenol 2-monooxygenase p0 component,; High confidence in function and specificity.
 
  
  0.957
lapM
Phenol 2-monooxygenase p2 component,; High confidence in function and specificity.
 
  
  0.953
lapN
Phenol 2-monooxygenase p3 component,; High confidence in function and specificity.
 
  
  0.950
lapL
Phenol hydroxylase p1 protein. Catabolizes phenol and some of its methylated derivates. P1 is required for growth on phenol and for in vitro phenol hydroxylase activity. Similar to SWISSPROT: sprot|DMPL_PSESP (52% Pseudomonas sp. (strain CF600), DmpL) / TREMBL: trembl|Q7WYF3 (67% Pseudomonas sp. KL28, LapL) InterPro: IPR003430 Phenol_Hydrox. Pfam: PF02332 Methane/Phenol/Toluene Hydroxylase. Part of the lap operon: In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. The lap [...]
 
  
  0.948
azo1843
Plant type ferredoxin like protein cofactor: binds 1 2fe-2s cluster (by similarity). Pfam: fer2 2Fe-2S iron-sulfur cluster binding do; Function unclear.
 
  
  0.929
xylF
2-hydroxy-muconic semialdehyde hydrolase; TREMBL:Q93JW6: 67% identity, 81% similarity. 2-hydroxymuconic semialdehyde hydrolase (HMSH). hydrolysis of C-C bonds in ketonic substances CONVERSION OF 2-HYDROXYMUCONIC ACID SEMIALDEHYDE TO 2-HYDROXYPENT-24-DIENOATE. Pfam: abhydrolase: alpha/Beta hydrolase fold; thioesterase domain Absence of transmembrane helices (TMHMM predicted) prfB: peptide chain release factor 2; High confidence in function and specificity.
 
  
 0.920
poxE
Probable phenol hydroxylase, subunit P4; Pseudomonas sp. phenol hydroxylase P4 protein (EC 1.14.13.7, (phenol 2-monooxygenase P4 component). CATABOLIZES PHENOL AND SOME OF ITS METHYLATED DERIVATIVES. P4 IS REQUIRED FOR GROWTH ON PHENOL AND FOR IN VITRO PHENOL HYDROXYLASE ACTIVITY; High confidence in function and specificity.
 
  
  0.909
poxA
Putative phenol hydroxylase, subunit P0. Homology to poxA of R. eutropha of 34% (trembl:O84958) This family consists of several bacterial phenol hydroxylase subunit proteins which are part of a multicomponent phenol hydroxylase. Some bacteria can utilise phenol or some of its methylated derivatives as their sole source of carbon and energy. The first step in this process is the conversion of phenol into catechol. Catechol is then further metabolised via the meta-cleavage pathway into TCA cycle intermediates. Pfam: Phenol hydrolase subunit no signal peptide no TMHs; Family membership.
 
  
  0.901
lapO
Phenol 2-monooxygenase p4 component,; High confidence in function and specificity.
 
  
  0.895
poxD
Probable phenol hydroxylase subunit,68% identity(84% similarity) to trEMBL:Q9RAF6,Phenol hydroxylase component [phyC] [Ralstonia sp. KN1]. TrEMBL;Q9ZNP4 Has PF02332:Methane/Phenol/Toluene Hydroxylase;IPR003430;Bacterial phenol hydroxylase (EC: 1.14.13.7) is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This family contains both the P1 and P3 polypeptides of phenol hydroxlase and the alpha and beta chain of methane hydroxylase protein A. Methane hydroxylase protein A (EC: 1.14.13.25) is responsible for the initial oxygenation of methane to metha [...]
 
  
  0.883
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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