STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lapHConversion of 4-oxalocrotonate into 2-oxopent-4-enoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todJ/xylI/xylJ/hpcG family, TREMBL:Q8RQD3 (56% identity); SWISSPROT:P23107. Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity. (267 aa)    
Predicted Functional Partners:
lapF
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.951
lapG
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.916
lapI
Oxaloacetate tautomerase; 4-oxalocrotonate isomerase,; High confidence in function and specificity; Belongs to the 4-oxalocrotonate tautomerase family.
 
  
 0.900
lapE
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todj/xyli/xylj/hpcg family, TREMBL:Q93JW5 (62% identity); SWISSPROT:P23107 (58% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 
0.899
mhpF
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.833
nahO
Acetaldehyde dehydrogenase; Involved in naphthalene degradation. Similar to TREMBL:Q52039 (83% identity); TREMBL:Q9ZI57 (76% identity); SWISPROT:P77580 (52% identity). InterPro (IPR003361): Acetaldehyde dehydrogenase Pfam (PF02396): Acetaldehyde dehydrogenase; High confidence in function and specificity.
 
  
 0.833
nahJ
4-oxalocrotonate tautomerase (EC 5.3.2.-) (4-OT). Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate. SPROT:Q9RHM8: 80% identity; 88% similarity InterPro: 4-oxalocrotonate tautomerase InterPro:IPR004370; Taut. ProDom: PD404143; Taut Pfam; PF01361; Tautomerase; 1. taut: 4-oxalocrotonate tautomerase helixturnhelix: reporting nucleic acid binding motif No transmembrane helices; High confidence in function and specificity.
    
 0.827
mhpD
MhpD protein; This family consist of various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds, TREMBL:Q51981 (54% identity); SWISSPROT:P77608 (50% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 
0.809
nahL
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate. Meta-cleavage pathway for the degradation of phenols, cresols and catechol. Belongs to the todj/xyli/xylj/hpcg family. Similar to TREMBL:Q93JW5 (75% identity); TREMBL:Q9ZI58 (65% identity); SWISSPROT:P23107 (73% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 
0.789
xylF
2-hydroxy-muconic semialdehyde hydrolase; TREMBL:Q93JW6: 67% identity, 81% similarity. 2-hydroxymuconic semialdehyde hydrolase (HMSH). hydrolysis of C-C bonds in ketonic substances CONVERSION OF 2-HYDROXYMUCONIC ACID SEMIALDEHYDE TO 2-HYDROXYPENT-24-DIENOATE. Pfam: abhydrolase: alpha/Beta hydrolase fold; thioesterase domain Absence of transmembrane helices (TMHMM predicted) prfB: peptide chain release factor 2; High confidence in function and specificity.
 
 
 0.777
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.