STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo1860Putative tautomerase Weak Homology with others similar proteins. Has 2 copies of PF01361, Tautomerase enzyme;IPR004370, Taut;This family includes the enzyme 4-oxalocrotonate tautomerase Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate. (139 aa)    
Predicted Functional Partners:
xylE
Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir|JE0112 (52%), to trembl|Q45459 (48%)and to sprot|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.
    
 0.843
azo1859
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q82N83 (22% identity); TREMBL:Q9F8V0 (21% identity). Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.
       0.785
lapH
Conversion of 4-oxalocrotonate into 2-oxopent-4-enoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todJ/xylI/xylJ/hpcG family, TREMBL:Q8RQD3 (56% identity); SWISSPROT:P23107. Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
    
 0.594
nahK
4-Oxalocrotonate decarboxylase; Similar to TREMBL:Q93JW1 (67% identity); TREMBL:Q9RHN0 (67% identity); SWISSPROT:P49155 (59% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
    
 0.594
nahI
2-hydroxymuconic semialdehyde dehydrogenase (HMSD). Homology to nahI of P. stutzeri of 73% (TREMBL:Q9S602) 2-HYDROXYMUCONIC ACID SEMIALDEHYDE CAN BE CONVERTED TO 2-HYDROXYPENT-24-DIENOATE EITHER DIRECTLY BY THE ACTION OF 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE (HMSH) OR BY THE ACTION OF THREE SEQUENTIAL ENZYMES THE FIRST OF WHICH IS HMSD. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs proA: gamma-glutamyl phosphate reductas.
     
  0.579
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.