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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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azo1882ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q89X55 (42% identity); SWISSPROT:P31219 (40% identity). InterPro (IPR003439): ABC transporter. InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). Pfam (PF00005): ABC trans [...] (225 aa)    
Predicted Functional Partners:
azo1881
ABC transporter permease protein; Similar to TREMBL:Q82US4 (29% identity). Pfam (DUF214): Predicted permease. TMHMM predicting 10 transmembrane helices; Specificity unclear.
 
 0.976
azo0832
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8DJ46 (29% identity); TREMBL:Q8YZK5 (29% identity). InterPro (IPR003838): Protein of unknown function DUF214. Pfam (DUF214): Predicted permease. TMHMM reporting four transmembrane helices. TC (3.A.1.122.): The Macr [...]
 0.926
azo0833
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8YZK5 (28% identity); TREMBL:Q8DJ46 (29% identity). Pfam (DUF214): Predicted permease. TMHMM reporting five transmembrane helices. TC (3.A.1.122.): The Macrolide Exporter (MacB) Family; Specificity unclear.
 0.897
azo3176
Permease component of an ABC-transporter system; Region start changed from 3485680 to 3485581 (99 bases).
 
 0.883
azo0056
Conserved hypothetical membrane protein. Homology to cv3942 of C. violaceum of 30% (trembl|Q7NR42) InterPro: DUF214 (IPR003838) Pfam: Predicted permease This is a family of predicted permeases and hypothetical transmembrane proteins. One member has been shown to transport lipids targeted to the outer membrane across the inner membrane, a step which requires ATP. Signal peptide 3 TMHs; Conserved hypothetical protein.
 
 0.881
lolE3
Permease component of an ABC transporter system; Part of a lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope); Specificity unclear.
 
 0.879
lolE1
Putative lipoprotein transporter, permease protein. Homology to lolE of E. coli of 36% (sprot|LOLE_ECOLI). Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of lolA (By similarity). Pfam: Predicted permease signal peptide 3 TMHs; High confidence in function and specificity.
 
 0.871
azo1880
Conserved hypothetical secreted protein. TREMBL:O86370 (36% identity); TREMBL:Q7U0W8 (36% identity). No domains predicted. SignalP reporting signal peptide. No TMHs; Conserved hypothetical protein.
     
 0.816
azo2910
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8FZX0 (58% identity); TREMBL:Q8U6Y9 (59% identity). InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). InterPro (IPR003439): ABC transporter. Pfam (PF00005): ABC transpor [...]
    
 0.806
macB
ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.782
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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