STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcdH2Glutaryl-CoA dehydrogenase mitochondrial precursor CATALYZES THE OXIDATIVE DECARBOXYLATION OF GLUTARYL-COA TO CROTONYL-COA AND CO(2) IN THE DEGRADATIVE PATHWAY OF L-LYSINE L-HYDROXYLYSINE AND L-TRYPTOPHAN METABOLISM. IT USES ELECTRON TRANSFER FLAVOPROTEIN AS ITS ELECTRON ACCEPTOR. Entry name TREMBL:Q88RH2 Prim. accession # Q88RH2 InterPro IPR006089; Acyl-CoA_dh. IPR006090; Acyl-CoA_dh_C. IPR006091; Acyl-CoA_dh_M. IPR006092; Acyl-CoA_dh_N. IPR009075; AcylCoADH_C_like. IPR009100; AcylCoA_dehyd_NM. Pfam PF00441; Acyl-CoA_dh; 1. PF02770; Acyl-CoA_dh_M; 1. PF02771; Acyl-CoA_dh_N; 1. Number [...] (393 aa)    
Predicted Functional Partners:
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
 
 0.943
azo1927
Probable enoyl-CoA hydratase; Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or3)-enoyl-CoA + H2O. Entry name TREMBL:Q7VU52 Prim. accession # Q7VU52 Identities = 124/266 (46%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; High confidence in function and specificity.
 
  0.942
fadB2
Short-chain enoyl-CoA hydratase activity. Activity:- 3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name TREMBL:Q8P986 Prim. accession # Q8P986 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1. Identities = 468/796 (58%) Prediction: Signal peptide Signal peptide probability: 0.980 Number of predicted TMHs: 0; Family membership.
  
 0.913
paaF1
Probable enoyl-CoA hydratase; COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Entry name :- SWISSPROT:PAAF_ECOLI Prim. accession # P76082 InterPro :- IPR001753; EnCoA_hydrtse. Pfam :- PF00378; ECH; 1. Identities = 109/250 (43%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership; Belongs to the enoyl-CoA hydratase/isomerase family.
  
  0.911
abmC
Probable enoyl-CoA hydratase; Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Entry name TREMBL:Q93FB6 Identities = 224/280 (80%) Prim. accession # Q93FB6 InterPro IPR001753; EnCoA_hydrtse. Pfam PF00378; ECH; 1. Number of predicted TMHs: 0; High confidence in function and specificity; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.901
azo1929
TREMBL:Q89PR6: 50% identity; 71% similarity Probable 4-hydroxybenzoyl-CoA thioesterase. InterPro:IPR008272; 4HBcoA_thiost_AS Pfam:4HBT:4-hydroxybenzoyl-CoA thioesterase TIGR00051: conserved hypothetical protein No transmembrane helices; Function unclear.
    
 0.788
etfA4
Probable electron transfer flavoprotein, alpha subunit. Homology to etfA of B. japonicum of 49% (sprot|ETFA_BRAJA) The electron transfer flavoprotein serves as a specific electron acceptor for some dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)(By similarity). InterPro: Electron transfer flavoprotein alpha-subunit (IPR001308) Pfam: Electron transfer flavoprotein alpha subunit no signal peptide no TMHs; High confidence in function and specificity.
 
 0.783
paaG5
Probable enoyl-CoA hydratase :- COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). Entry name :- SWISSPROT:PAAG_ECOLI InterPro :-IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Identities = 75/247 (30%) Number of predicted TMHs: 0; Family membership; Belongs to the enoyl-CoA hydratase/isomerase family.
  
  0.778
caiD
Putative Carnitinyl-CoA dehydratase; Function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotobetainyl-CoA. Entry name CAID_ECO57 Primary accession number Q8XA35 InterPro IPR001753; EnCoA_hydrtse. Pfam PF00378; ECH; 1. Identities = 30% Prediction: Non-secretory protein Signal peptide probability: 0.003 Number of predicted TMHs: 0; Family membership.
   
  0.776
paaG6
Putative enoyl-CoA hydratase paaG; Function:- Could possibly oxidizes fatty acids using specific components (By similarity). Activity:-(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. Entry name:- SWISSPROT:PAAG_ECOLI InterPro:- IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Identities = 65/222 (29%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
  
  0.774
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.