STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
xylF2-hydroxy-muconic semialdehyde hydrolase; TREMBL:Q93JW6: 67% identity, 81% similarity. 2-hydroxymuconic semialdehyde hydrolase (HMSH). hydrolysis of C-C bonds in ketonic substances CONVERSION OF 2-HYDROXYMUCONIC ACID SEMIALDEHYDE TO 2-HYDROXYPENT-24-DIENOATE. Pfam: abhydrolase: alpha/Beta hydrolase fold; thioesterase domain Absence of transmembrane helices (TMHMM predicted) prfB: peptide chain release factor 2; High confidence in function and specificity. (284 aa)    
Predicted Functional Partners:
lapB2
Catechol 2,3-dioxygenase (metapyrocatechase); In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. Catechol 2,3-dioxygenase LapB,; High confidence in function and specificity.
 
  
 0.941
lapB1
Catechol 2,3-dioxygenase; In Pseudomonas sp. strain KL28 the genes,designated as lap (for long-chain alkylphenols), encoding enzymes for the catabolic 3- and 4-alkylphenol degradation pathway. The lap genes are located in a 13.2 kb region with 14 ORFs in the order lapRBKLMNOPCEHIFG and with the same transcriptional orientation. Catechol 2,3-dioxygenase LapB,; High confidence in function and specificity.
 
  
 0.920
xylE
Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir|JE0112 (52%), to trembl|Q45459 (48%)and to sprot|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.
 
  
 0.911
nahL
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate. Meta-cleavage pathway for the degradation of phenols, cresols and catechol. Belongs to the todj/xyli/xylj/hpcg family. Similar to TREMBL:Q93JW5 (75% identity); TREMBL:Q9ZI58 (65% identity); SWISSPROT:P23107 (73% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
 
 0.889
mhpD
MhpD protein; This family consist of various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds, TREMBL:Q51981 (54% identity); SWISSPROT:P77608 (50% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
 
 0.869
nahK
4-Oxalocrotonate decarboxylase; Similar to TREMBL:Q93JW1 (67% identity); TREMBL:Q9RHN0 (67% identity); SWISSPROT:P49155 (59% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
 
 0.813
lapH
Conversion of 4-oxalocrotonate into 2-oxopent-4-enoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todJ/xylI/xylJ/hpcG family, TREMBL:Q8RQD3 (56% identity); SWISSPROT:P23107. Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
 
 0.777
lapE
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todj/xyli/xylj/hpcg family, TREMBL:Q93JW5 (62% identity); SWISSPROT:P23107 (58% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
 
 0.740
todE
Probable 3-methylcatechol 2,3-dioxygenase; Methylcatechol 2,3-dioxygenase, TodE, is involved in the degradation of toluene. Similar to sprot|TODE_PSEPU (38%) and to trembl|Q52031 (36%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Specificity unclear.
 
  
  0.727
nahI
2-hydroxymuconic semialdehyde dehydrogenase (HMSD). Homology to nahI of P. stutzeri of 73% (TREMBL:Q9S602) 2-HYDROXYMUCONIC ACID SEMIALDEHYDE CAN BE CONVERTED TO 2-HYDROXYPENT-24-DIENOATE EITHER DIRECTLY BY THE ACTION OF 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE (HMSH) OR BY THE ACTION OF THREE SEQUENTIAL ENZYMES THE FIRST OF WHICH IS HMSD. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs proA: gamma-glutamyl phosphate reductas.
  
  
  0.722
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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