STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mhpB2,3-dihydroxyphenylpropionate 1,2-dioxygenase; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family. (317 aa)    
Predicted Functional Partners:
ohpC
2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase; Hypothetical protein Rv2715/MT2788/Mb2734. TREMBL:Q9KH20: 58% identity, 73% similarity 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase; OhpC [Rhodococcus sp.] Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate. Pfam: alpha/ beta hydrolase; Ndr family; B12 binding domain. No signal peptide (Signal P predicted) or transmembrane helices (TMHMM predited) TIGRFAM: Co A. E activ TIGR00044: conserved hypothetical protein; Family membership.
 
 
  0.877
mhpD
MhpD protein; This family consist of various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds, TREMBL:Q51981 (54% identity); SWISSPROT:P77608 (50% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 0.790
vanB1
Probable vanillate O-demethylase oxidoreductase (Vanillate degradation ferredoxin-like protein). Homology to vanB of P. sp HR199 of 40% (sprot|VANB_PSEUH). The vanillate demethylase (EC:1.14.13.82) consists of two proteins: an oxygenase and an oxygenase reductase (VanA and VanB). This enzyme is involved in the vanillate degradation, a key intermediate in the degradation of lignin. InterPro: NADH:cytochrome b5 reductase (CBR)(IPR001834); Ferredoxin (IPR001041); Oxidoreductase FAD and NAD(P) binding domain (IPR001433) Pfam: Oxidoredutase FAD-binding domain; Oxidoreductase NAD-binding dom [...]
  
  
 0.692
vanB2
Probable vanillate O-demethylase oxidoreductase (Vanillate degradation ferredoxin-like protein). Homology to vanB of P. sp HR199 of 42% (sprot|VANB_PSEUH). The vanillate demethylase (EC:1.14.13.82) consists of two proteins: an oxygenase and an oxygenase reductase (VanA and VanB). This enzyme is involved in the vanillate degradation, a key intermediate in the degradation of lignin. Pfam: Oxidoredutase FAD-binding domain; Oxidoreductase NAD-binding domain; 2Fe-2S iron-sulfur cluster binding domain no signal peptide no TMHs; Family membership.
  
  
 0.689
ligA2
[EC:1.13.11.8], Protocatechuate 4,5-dioxygenase alpha chain (EC 1.13.11.8) (4,5-PCD)., Aromatic-ring-opening dioxygenase LigAB, LigA subunit; High confidence in function and specificity.
 
  
  0.667
mhpF
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
  
 0.666
mhpE
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
    0.629
mhpA
Putative oxygenase. 3-(3-hydroxy-phenyl)propionate hydroxylase (EC 1.14.13.-), InterPro: Aromatic-ring hydroxylase (flavoprotein monooxygenase); Specificity unclear.
  
 
 0.625
ligI
Probable 2-pyrone-4,6-dicarboxylate hydrolase. Homology to ligI of S. paucimobilis of 55% (tremble:O87170) Pfam: Amidohydrolase no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.611
ligC
Hypothetical oxidoreductase yrbE (EC 1.-.-.-). TREMBL:Q93PS4:90% identity; 93% similarity. This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family in Swiss-Prot. GFO is a glucose--fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyze the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and gala [...]
 
  
 0.599
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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