STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
azo1988Conserved hypothetical protein; TREMBL:Q8XYC3: 64% identity, 75% similarity Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form a part of the active site. InterPro:IPR007325; Cyclase. Pfam: PF04199; Cyclase Absence of signal peptide. Absence of transmembrane helices; Function unclear. (261 aa)    
Predicted Functional Partners:
azo1989
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q7WG84 (46% identity); SWISSPROT:P17611 (30% identity). Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.
 
    0.899
azo1987
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,; Specificity unclear.
 
     0.887
azo1986
Conserved hypothetical protein; Entry name TREMBL:Q89PQ1 Prim. accession # Q89PQ1 Identities = 241/381 (63%) Thiolase, N-terminal domain (Pfam predicted) Prediction: Non-secretory protein Signal peptide probability: 0.00 Number of predicted TMHs: 0.
 
     0.864
carBa2
Putative dioxygenase, hydroxylase small component; Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation. Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBa. Involved in the aerobic degradation of carbazole by P.resinovorans sp. strain CA10. XlyX: Benzoate 12-dioxygenase alpha subunit (EC 1.14.12.10). DEGRADATION OF BENZOATE TO 2-HYDRO-12-DIHYDROXYBENZOATE (DHB). Benzoate 12-dioxygenase beta subunit (EC 1.14.12.10). DEGRADATION OF BENZOATE TO 2-HYDRO-12-DIHYDROXYBENZOATE (DHB). THE BETA SUBUNIT MAY BE RESPONSIBLE FOR THE SUBST [...]
 
     0.861
azo1981
Conserved hypothetical indolepyruvate ferredoxin oxidoreductase, beta subunit. Homology to rsc1828 of R. solanacearum of 53% (trembl|Q8XYD0). Pfam: Pyruvate ferredoxin/flavodoxin oxidoreductase. no signal peptide. no TMHs; Conserved hypothetical protein.
 
  
  0.858
azo1980
Conserved hypothetical indolepyruvate oxidoreductase, alpha subunit. Homology to mlr5448 of M. loti of 69% (trembl|Q98BS4). CATALYZES THE FERREDOXIN-DEPENDENT OXIDATIVE DECARBOXYLATION OF ARYLPYRUVATES (BY SIMILARITY). no signal peptide. no TMHs; Conserved hypothetical protein.
 
     0.824
carBb2
Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation. Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBb. Involved in the aerobic degradation of carbazole by P.resinovorans sp. strain CA10. XlyY: Benzoate 12-dioxygenase beta subunit (EC 1.14.12.10). DEGRADATION OF BENZOATE TO 2-HYDRO-12-DIHYDROXYBENZOATE (DHB); High confidence in function and specificity.
 
     0.819
azo1985
Putative AMP-binding protein; Similar to TREMBL:Q89PS8 (59% identity). InterPro (IPR000873): AMP-dependent synthetase and ligase. Pfam (PF00501): AMP-binding enzyme; Function unclear.
 
  
  0.782
carBb1
Putative dioxygenase hydroxylase large component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation. 81% simialr to a Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBb. Involved in the aerobic degradation of carbazole by Pseudomonas resinovorans sp. strain CA10. TREMBL:Q8GI28 InterPro:IPR005806; Rieske_reg.IPR001663; Ring_hydroxyl_A. Pfam:PF00355; Rieske; 1. PF00848; Ring_hydroxyl_A; [...]
  
     0.701
carBa1
Putative dioxygenase, hydroxylase small component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. The beta subunit is may be responsible for the substrate specificity of the enzyme. Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBa. Involved in the aerobic degradation of carbazole by P.resinovorans sp. strain CA10. XlyY: Benzene 12-dioxygenase beta subunit (EC 1.14.12.3), involved in benzoate degradation.Degradation of benzoate to 2-hydro-12-dihydroxybenzoate (dhb).; Conserved hypotheti [...]
 
     0.698
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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