STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
iscS1Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (403 aa)    
Predicted Functional Partners:
iscU
NifU-related protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
 
 0.998
iscS2
Probable cysteine desulfurase (NifS protein homolog). Homology to iscS of M. thermophila of 40% (sprot|ISCS_METTE) Catalyzes the removal of elemental sulfur from cysteine to produce alanine (By similarity). InterPro: Aminotransferase class-V (IPR000192) Pfam: aminotransferase class-V no signal peptide no TMHs ahpD: alkylhydroperoxidase AhpD; Family membership.
 
  
 
0.989
fdx2
Fdx2 protein; Ferredoxin 2Fe-2S. Homology to fdx of E. coli of 70% (sprot|FER_ECOLI). Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron- sulfur proteins. InterPro: Ferredoxin (IPR001055); Adrenodoxin (IPR001055) Pfam: 2Fe-2S iorn-sulfur cluster binding domain no signal peptide no TMHs; High confidence in function and specificity.
 
 0.976
nifQ
Putative NifQ protein. Homology to nifQ of A. vinelandii of 33% (sprot|NIFQ_AZOVI(SRS) NifQ is involved in early stages of the biosynthesis of the iron-molybdenum cofactor (FeMo-co), which is an integral part of the active site of dinitrogenase [2]. The conserved C-terminal cysteine residues may be involved in metal binding. Pfam: NifQ no signal peptide no TMHs; Family membership.
  
 0.967
hscB
Putative co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.967
cyaY
Putative CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 
 0.967
azo2919
Conserved hypothetical protein. Homology to rsc0810 of R. solanacearum of 71% (trembl|Q8Y180). InterPro: Uncharacterized protein family UPF0033 (IPR001455). Pfam: Uncharacterized protein family UPF0033. no signal peptide. no TMH; Family membership; Belongs to the sulfur carrier protein TusA family.
   
 0.952
azo2018
RrF2 family protein. These are small proteins of 12 to 18 kD which seem to contain a signal sequence, and may represent a family of probable transcriptional regulators. Similar to SWISSPROT: sprot|YOR2_AZOVI (50% Azotobacter vinelandii, hypothetical upf0074 protein) / TREMBL: trembl|Q8Y0M5 (72% Ralstonia solanacearum (Pseudomonas solanacearum), hypothetical protein rsc1018) Pfam: PF02082 Transcriptional regulator. TIGRFAM: TIGR00738 rrf2 family protein (Uncharacterized protein family UPF0074 / putative transcriptional regulator). Signal P reporting signal peptide. HTH reporting nucleic [...]
  
 
 0.949
azo2804
Adenylyltransferase, putative; Dinucleotide-utilizing enzyme involved in molybdopterin and/or thiamine biosynthesis Belongs to the hesA/moeB/thiF family, by similarity. TIGR00292: thiazole biosynthesis enzyme; High confidence in function and specificity.
   
 0.940
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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