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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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azo2048Hypothetical protein yfdR. The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria,archaea and eukaryotes TREMBL:Q8HAA3: 41% identity,52% similarity InterPro:IPR003607; Met_phsphohydro. SMART:SM00471; HDc hstdl_phs_rel: histidinol phosphatase-r No signal peptide No transmembrane helices; Function unclear. (198 aa)    
Predicted Functional Partners:
surE
Phosphoric-monoester phosphohydrolase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.821
azo3643
Probable dNTP triphosphohydrolase. Homology to an orf of Thermus thermophilus of 46% (gi|37572416|dbj|BAC98488.1|(NCBI ENTREZ)). Pfam: HDc. The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The fact that all the highly conserved redisues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins. [...]
  
 
  0.819
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.807
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
  0.793
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.793
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
  0.793
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
  0.792
yaiE
Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
  0.792
azo3611
Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
     
  0.792
lhpp
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase. Enzyme that hydrolyzes not only oxygen-phosphorus bonds in inorganic pyrophosphate but also nitrogen-phosphorus bonds in phospholysine,phosphohistidine and imidodiphosphate in vitro. 38% HAD_SF_IIA.IPR006355; HAD_SF_IIA_hyp2.IPR005834; Hydrolase. Pfam:PF00702;Hydrolase; 1. TIGRFAMs:TIGR01460; HAD-SF-IIA; 1.TIGR01458; HAD-SF-IIA-hyp3; 1. TMHelix:1; High confidence in function and specificity.
  
 
 0.644
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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