STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo2062Conserved hypothetical peptidyl-prolyl cis-trans isomerase. Homology to slyD of E. coli of 41% (sprot|SLYD_ECOLI) but around 30 aa at the C-terminus are missing. Peptidylprolyl isomerases accelerate protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. InterPro: FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase) (IPR001179). Pfam: FKBP-type peptidyl-prolyl cis-trans isomerase. no signal peptide. no TMHs; Family membership. (161 aa)    
Predicted Functional Partners:
bcp1
Putative bacterioferritin comigratory protein. Homology to bcp of E. coli of 37% (srot:BCP_ECOLI) Interpro: Alkyl hydroperoxid reductase/ Thiol specific antioxidant / Mal Alergern (IPR000866) Pfam: AhpcC/TSA family no signal peptide no TMH; Family membership.
       0.799
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
    
 
 0.760
hypB
Probable hydrogenase accessory protein HypB. Homology to hypB of E. coli of 56% (sprot|HYPB_ECOLI). IS REQUIRED FOR THE FORMATION OF HYDROGENASE ISOENZYMES. AFFECTS SOME ASPECT OF THE PROCESSING OF HYDROGENASES and NICKEL INCORPORATION scince HYPB GENE LESIONS CAN BE COMPLEMENTED BY HIGH NICKEL ION CONCENTRATION IN THE MEDIUM. Pfam: HypB/UreG nucleotide-binding domain Tigrfam: hypB: hydrogenase accessory protein Hyp no signal peptide no TMHs; High confidence in function and specificity.
    
 
 0.760
rpsJ
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
   
  
 0.583
dppF
Hypothetical ABC transporter ATP-binding protein yliA. PROBABLY PART OF A BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM YLIABCD. PROBABLY RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM. TREMBL:Q82S74: 52% identity, 64% similarity. InterPro: IPR003593; AAA_ATPase. No signal peptide No transmembrane helices. IPR003439; ABC_transporter. IPR010066; Oligo_HPY. Pfam:PF00005; ABC_tran; 2. ProDom: PD000006; ABC_transporter; 1. SMART:SM00382; AAA; 2. TIGRFAMs TIGR01727; oligo_HPY mobB: molybdopterin-guanine dinucleotid; High confidence in function and specificity.
       0.522
icd1
Isocitrate dehydrogenase [NADP]. Homology to icd1 of A. eutropus of 75% (trembl|Q8KLU5) Isocitrate dehydrogenase is an important enzyme of the TCA which catalyzes the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+ Pfam: Isocitrate/isopropylmalate dehydrogenase Tigrfam: prok_nadp_idh: isocitrate dehydrogenase no signal peptide no TMHs; High confidence in function and specificity.
  
    0.491
lexA
Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
     
 0.441
trxA1
Thioredoxin-disulfide reductase. Homology to trxA of T. ferrooxidans of 69% (THIO_THIFE). Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide. InterPro: Thioredoxin (IPR006662) Pfam: Thioredoxin no signal peptide no TMHs; Specificity unclear.
   
   0.436
ttcA
Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
 
     0.432
norM
Multidrug resistance protein; The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae,and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. Functions as a Na(+)/drug antiporter. These proteins have 12 probable TMS,TREMBL:Q7NXN3 (35% identity); SWISSPROT:Q9K015 (32% identity). Pfam (UPF0013): Uncharacterized membrane protein family. TIGRFAM (TIGR00797): matE. TMHMM reporting 11 transmembrane helice [...]
       0.427
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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