STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
azo2067Arsenate reductase (EC 1.20.4.1) (Arsenical pump modifier). REDUCTION OF ARSENATE [AS(V)] TO ARSENITE [AS(III)]. THIS PROTEIN EXPANDS THE SUBSTRATE SPECIFICITY OF ARSAB PUMP WHICH CAN EXTRUDE ARSENITE AND ANTIMONITE TO ALLOW FOR ARSENATE PUMPING AND RESISTANCE. arsC: arsenate reductase; High confidence in function and specificity. (116 aa)    
Predicted Functional Partners:
azo2068
Conserved hypothetical protein. Homology to rsc2890 of R. solanacearum of 53% (trembl|Q8XVE1). InterPro: PDZ domain (also known as DHR or GLGF)(IPR001478). Pfam: PDZ domain (also known as DHR or GLGF); M61 glycyl aminopeptidase PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates. They may function in targeting signalling molecules to sub-membranous sites. Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities. Glyc [...]
       0.773
gcvH
Glycine cleavage system H protein [gcvH]; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
  0.729
gcvP
Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.715
gcvT
Glycine cleavage T proteins are part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. The T-protein is an aminomethyl transferase that catalyses the following reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein Similar to sprot|GCST_NITEU (60%). Pfam: Glycine cleavage T-protein (aminomethyltransferase) TIGRfam (TIGR00528): Glycine cleavage T-protein (aminomethyl transferase); High confidence in function and specificity.
     
  0.715
rpoA
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.694
azo2283
Conserved hypothetical protein; Similar to TREMBL:Q92PT6 (40% identical); TREMBL:Q98MM5 (39% identical).
    
 
 0.568
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
   
 
  0.523
arsB
Putative arsenical-resistance protein arsB,; Family membership.
     
 0.436
azo1887
Conserved hypothetical protein. Homology to RS03577 of R.solanacearum of 66% (tremble:Q8XXV4). Has PF03883,Protein of unknown function (DUF328); IPR005583; Members of this family are functionally uncharacterised. They are about 250 amino acids in length. No signal peptide. No TMHs; Belongs to the UPF0246 family.
 
     0.427
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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