STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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acsAPutative acetoacetyl-CoA synthase; INVOLVED IN POLY-3-HYDROXYBUTYRATE DEGRADATION. ACTIVATES ACETOACETATE TO ACETOACETYL-COA. catalytic activity :-atp + acetate + coa = amp + diphosphate + acetyl-coa. Entry name SWISSPROT:ACSA_ECOLI Prim. accession # P27550 Identities = 164/624 (26%) InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership. (661 aa)    
Predicted Functional Partners:
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
  
 
 0.889
fadB2
Short-chain enoyl-CoA hydratase activity. Activity:- 3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name TREMBL:Q8P986 Prim. accession # Q8P986 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1. Identities = 468/796 (58%) Prediction: Signal peptide Signal peptide probability: 0.980 Number of predicted TMHs: 0; Family membership.
  
 
 0.889
mvaB
Hydroxymethylglutaryl-CoA lyase, MvaB. It catalyses the conversion of (S)-3-hydroxy-3-methylglutaryl-CoA to acetyl-CoA and acetoacetate during the final step of ketogenesis and leucine catabolism. Similar to trembl|Q8QGJ4 (60%) and to pir|H83394 (56%). InterPro (PF00682): HMG-CoA Lyase-like family; High confidence in function and specificity.
 
 
 0.886
fadAx
Probable acyl-CoA thiolase. Homology to fadAx of P. putida of 67% (gnl|keqq|ppu:PP2215(KEGG)). IPR002155; Thiolase. Pfam PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC:2.3.1.9) and 3-ketoacyl-CoA thiolase (EC:2.3.1.16). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid -oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of a [...]
  
 
 0.876
fadA1
Probable 3-ketoacyl-CoA thiolase; Subunit of fatty acid oxidation complex, 3-keto-acyl-coa-thiolase. Activity:-acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA Entry name TREMBL:Q8G967 Prim. accession # Q8G967 Identities = 284/425 (66%) InterPro IPR002155; Thiolase. Pfam PF02803; Thiolase_C; 1. PF00108; Thiolase_N; 1. Number of predicted TMHs: 0 Prediction: Non-secretory protein Signal peptide probability: 0.000; Family membership; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.876
thlA
Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase):- catalytic activity:-2 acetyl-coa = coa + acetoacetyl-coa. Entry name SWISSPROT:THLA_CLOAB Prim. accession # P45359 Identities = 205/392 (52%) InterPro IPR002155; Thiolase. Pfam PF00108; thiolase; 1. Prediction: Non-secretory protein Signal peptide probability: 0.022 Number of predicted TMHs: 0; Family membership; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.876
hbdA
Probable 3-hydroxybutyryl-CoA dehydrogenase; Activity:- (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+ Entry name :- TREMBL:Q89GX2 Prim. accession # Q89GX2 Identities = 177/280 (63%) InterPro:- IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR000205; NAD_BS. Pfam :-PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. Prediction: Signal peptide Signal peptide probability: 0.873 Number of predicted TMHs: 0; Family membership.
   
 
 0.865
paaH2
Probable 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta- hydroxybutyryl-CoA dehydrogenase) (BHBD). Activity:- 3-acetoacetyl-CoA + NADPH = (S)-3-hydroxybutanoyl-CoA + NADP+ Entry name TREMBL:Q9F9V1 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR002110; ANK. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 2. PF02737; 3HCDH_N; 1. Identities = 319/502 (63%) Prediction: Signal peptide Signal peptide probability: 0.906 Number of predicted TMHs: 0; Family membership.
   
 
 0.851
pta
Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 
 0.812
azo2150
Probable Hypothetical protein AQ_1494. TREMBL:Q7WIS5: 37% identity; 51% similarity. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC: 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters. InterPro:IP [...]
    
  0.720
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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